25775-90-0
25775-90-0 structure
- Name: (Z)-Capsaicin
- Chemical Name: (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
- CAS Number: 25775-90-0
- Molecular Formula: C18H27NO3
- Molecular Weight: 305.412
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2018-06-15 21:26:54
- Modify Date: 2024-01-05 19:21:00
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(Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.
| Name | (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide |
|---|---|
| Synonyms |
(6Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
cis-8-methyl-N-vanillyl-6-nonenamide (6Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide (Z)-8-Methyl-N-vanillyl-6-noneamide cis-capsaicin Civanex Zucapsaicin Civamide (Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide (Z)-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6Z)- (Z)-CAPSAICIN |
| Description | (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain. |
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| Related Catalog | |
| Target |
TRPV1 receptor[1] |
| In Vitro | (Z)-Capsaicin is the cis isomer of capsaicin, acting as a TRPV1 agonist. (Z)-Capsaicin may also blocks the neruonal calcium channel[1]. |
| In Vivo | (Z)-Capsaicin (Zucapsaicin) significantly attenuates nociceptive behavior after oral administration in rats. (Z)-Capsaicin is also tolerated in the primary or recurrent experimental genital herpes simplex virus infection in guinea pigs[1]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 511.5±50.0 °C at 760 mmHg |
| Molecular Formula | C18H27NO3 |
| Molecular Weight | 305.412 |
| Flash Point | 263.1±30.1 °C |
| Exact Mass | 305.199097 |
| PSA | 58.56000 |
| LogP | 3.33 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.524 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2924299090 |
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25775-90-0 |
| Literature: Janusz, John M.; Buckwalter, Brian L.; Young, Patricia A.; LaHann, Thomas R.; Farmer, Ralph W.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2595 - 2604 |
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| Literature: Journal of Medicinal Chemistry, , vol. 36, # 18 p. 2595 - 2604 |
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| Literature: Journal of Organic Chemistry, , vol. 54, p. 3477 - 3478 |
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| Literature: Journal of Organic Chemistry, , vol. 54, p. 3477 - 3478 |
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| Literature: Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071 |
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| Literature: Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071 |
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| Literature: Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071 |
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| Literature: Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071 |
| Precursor 8 | |
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| DownStream 1 | |
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |