Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (Z)-N-(4-HYDROXY-3-METHOXYBENZYL)-8-METHYLNON-6-ENAMIDE
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Purity: 98.0%
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25775-90-0

25775-90-0 structure

Name: (Z)-Capsaicin
Chemical Name: (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
CAS Number: 25775-90-0
Molecular Formula: C₁₈H₂₇NO₃
Molecular Weight: 305.412
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2018-06-15 21:26:54
Modify Date: 2026-07-03 10:38:34
(Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.

Name	(Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Synonyms	civamide (Z)-8-Methyl-N-vanillyl-6-nonenaMide (Z)-N-[(4-Hydoxy-3-methoxyphenyl)methyl]-8-metyl-6-nonenamide Civanex Civamide cis-Capsaicine (6Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide (z)-6-nonenamid 8-Methyl-N-vanillyl-6-nonenamide cis-8-methyl-N-vanillyl-6-nonenamide (6Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide Zucapsaicin（cis-Capsaicin） 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6Z) (Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide (Z)-8-Methyl-N-(4-hydroxy-3-methoxybenzyl)-6-noneneamide Zucapsaicin (Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide (Z)-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide (Z)-Capsaicin、Civamide (6Z)-N-[(4-Hydroxy-3-Methoxyphenyl)Methyl]-8-Methyl-6-nonenaMide ZUCAPSAICIN;CIS-CAPSAICIN;CIVAMIDE;(Z)-CAPSAICIN cis-capsaicin Zucapsaicin ((Z)-Capsaicin) (Z)-CAPSAICIN / Zucapsaicin Zucapsaicin,civaMide Civamide cis-Capsaicin (Z)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE D3-cis-Capsaicin n-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide(z) (Z)-8-Methyl-N-vanillyl-6-noneamide Civamide (Zucapsaicin) (Z)-N-(4-Hydroxy-3-Methoxybenzyl)-8-Methylnon-6-enaMide (Z)-CAPSAICIN

Description	(Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	TRPV1 receptor[1]
In Vitro	(Z)-Capsaicin is the cis isomer of capsaicin, acting as a TRPV1 agonist. (Z)-Capsaicin may also blocks the neruonal calcium channel[1].
In Vivo	(Z)-Capsaicin (Zucapsaicin) significantly attenuates nociceptive behavior after oral administration in rats. (Z)-Capsaicin is also tolerated in the primary or recurrent experimental genital herpes simplex virus infection in guinea pigs[1].
References	[1]. Bourne N, et al. Civamide (cis-capsaicin) for treatment of primary or recurrent experimental genital herpes. Antimicrob Agents Chemother. 1999 Nov;43(11):2685-8.

Density	1.0±0.1 g/cm3
Boiling Point	511.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₇NO₃
Molecular Weight	305.412
Flash Point	263.1±30.1 °C
Exact Mass	305.199097
PSA	58.56000
LogP	3.33
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.524

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA8540000

CHEMICAL NAME :: 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (Z)-

CAS REGISTRY NUMBER :: 25775-90-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H27-N-O3

MOLECULAR WEIGHT :: 305.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 36,2595,1993

HS Code	2924299090

1196-92-5

31467-61-5

~68%

25775-90-0

Literature: Janusz, John M.; Buckwalter, Brian L.; Young, Patricia A.; LaHann, Thomas R.; Farmer, Ralph W.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2595 - 2604

31467-60-4

25775-90-0

Literature: Journal of Medicinal Chemistry, , vol. 36, # 18 p. 2595 - 2604

50889-29-7

25775-90-0

Literature: Journal of Organic Chemistry, , vol. 54, p. 3477 - 3478

121-33-5

25775-90-0

Literature: Journal of Organic Chemistry, , vol. 54, p. 3477 - 3478

502-44-3

25775-90-0

Literature: Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071

6654-36-0

25775-90-0

Literature: Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071

4547-43-7

25775-90-0

Literature: Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071

112375-42-5

25775-90-0

Literature: Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071

Precursor 8
1196-92-5 31467-60-4 50889-29-7 121-33-5
502-44-3 6654-36-0 4547-43-7 112375-42-5
DownStream 1
19408-84-5

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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