Shanghai Nianxing Industrial Co., Ltd
China
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BioBioPha
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Dihydrocapsaicin
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19408-84-5

19408-84-5 structure

19408-84-5 structure

Name: Dihydrocapsaicin
Chemical Name: dihydrocapsaicin
CAS Number: 19408-84-5
Molecular Formula: C₁₈H₂₉NO₃
Molecular Weight: 307.428
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-05-26 08:00:00
Modify Date: 2026-07-02 00:13:39
Dihydrocapsaicin is a natural capsaicin, acts as a selective TRPV1 agonist, and also increases p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection[1][2].

Name	dihydrocapsaicin
Synonyms	N-(4-Hydroxy-3-methoxybenzyl)-8-methylnonanamide Dihydro capsaicin - Synthetic Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl (1Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnonanimidic acid 8-methyl-nonanoic acid vanillylamide N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE (E)-N-[(4-Hydroxy-3-methoxyphenyl)-8-methyl-6-nonenamide Dihydrocapsaicin from Capsicum annuum L 8-methyl-N-vanillylnonanamide approx.* from ca Valine Impurity 77 Dihydro capsaicin - Natural extraction Nonanamide,8-methyl-N-vanillyl Dihydro Capsaicin MFCD00017259 CAPSAICIN/8-METHYL-NONANOICACIDVANILLYLAMIDE Dihydrocapsaicin //BP CCRIS1589 N-(4-Hydroxy-3-methoxybenzyl)-8-methylnomide (E)-8-METHYL-NON-6-ENOIC ACID 4-HYDROXY-3-METHOXY-BENZYLAMIDE (E)-CAPSAICIN 6,7-Dihydrocapsaicin N-(4-Hydroxy-3-methoxybenzyl) Dihydrocapsaicin from Capsicum annuum N-[(4-hydroxy-3-methoxy-1-cyclohexa-2,4-dienyl)methyl]-8-methyl-6-nonenamide DIHYDROCAPSAICIN, NATURAL Dihydrocapsaicin Standd Dihydrocapsaicin in Methanol 8-METHYL-N-VANILLYLNONANAMIDE APPROX.* FROM CAPS (E)-N-([4-HYDROXY-3-METHOXYPHENYL]METHYL)8-METHYL-6-NONEAMIDE N-(3-Methoxy-4-hydroxybenzyl)-8-methylnonanamide 8-Methyl-N-vanillyl-nonamide N-(4-hydroxy-3-methoxy-benzyl)-8-methyl-pelgonamide CAPSAICIN, NATURAL Dihydrocapsaicin std N-(4-hydroxy-3-Methoxybenzyl)-8-MethylnonanaMide 6,7-dihydrocapsaicin Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide N-[(4-Hydroxy-3-methoxy-phenyl)methyl]-8-methyl-nonanamide CAPSAICINE 8-methylnonanamide 8-METHYL-N-VANILLYLNONANAMIDE DIHYDROCAPSAICIN(P) TRANS-8-METHYL-N-VANILLYL-6-NONENAMIDE N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6E-NONENAMIDE 8-METHYL-N-VANILLYL-TRANS-6-NONENAMIDE N-(4-hydroxy-3-methoxybenzyl)isodecanamide 8-methyl-n-vanillyl-nonanamid 8-METHYL-N-VANILLYL-6-NONENEAMIDE Dihydrocapsaicin-RM 19-5 Dihydrocapsaicin N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methylnonenamide N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnonanamide Dihydrocapsaicin, froM CapsicuM annuuM Dihydrocapsaicin (25 mg) EINECS 206-969-8 ihydrocapsaicin 8-Methyl-N-vanillylnonanamide

Description	Dihydrocapsaicin is a natural capsaicin, acts as a selective TRPV1 agonist, and also increases p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
References	[1]. Gao F, et al. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010 Apr;55(4):1018-25. [2]. Dihydrocapsaicin, et al. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017 Sep 15;1671:18-25.

Density	1.0±0.1 g/cm3
Boiling Point	457.3±55.0 °C at 760 mmHg
Melting Point	62-65 °C(lit.)
Molecular Formula	C₁₈H₂₉NO₃
Molecular Weight	307.428
Flash Point	230.4±31.5 °C
Exact Mass	307.214752
PSA	58.56000
LogP	4.72
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.508
Storage condition	2-8°C
Water Solubility	H2O: insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA5998000

CHEMICAL NAME :: Nonanamide, 8-methyl-N-vanillyl-

CAS REGISTRY NUMBER :: 19408-84-5

BEILSTEIN REFERENCE NO. :: 2815150

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H29-N-O3

MOLECULAR WEIGHT :: 307.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 5 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 48,109,1989

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R25;R36/37/38
Safety Phrases	S22-S26-S28-S36/39-S45-S36/37/39
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	RA8530000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	3302109090

Precursor 9
10266-06-5 201230-82-2 7149-10-2 404-86-4
25775-90-0 502-44-3 6654-36-0 4547-43-7
59320-77-3
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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