Name | 1-methyl-3-(1-methylindol-3-yl)-4-(pentylamino)pyrrole-2,5-dione |
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Synonyms |
IM-54
Necrosis Inhibitor,IM-54 1-Methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-1H-pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 1-methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)- IN1208 |
Description | IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death[1][2]. |
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Related Catalog | |
In Vitro | IM-54 selectively inhibits oxidative stress-induced necrosis, but it does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis[1]. IM-54 shows strong inhibition of H2O2-induced necrosis, with an IC50 of 0.25 μM against HL-60 cells treated with H2O2[1]. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 511.5±50.0 °C at 760 mmHg |
Molecular Formula | C19H23N3O2 |
Molecular Weight | 325.405 |
Flash Point | 263.1±30.1 °C |
Exact Mass | 325.179016 |
PSA | 54.34000 |
LogP | 3.81 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.615 |
Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
RIDADR | UN 2811 6.1 / PGIII |