DC Chemicals Limited
China
Product Name: Anabaseine
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

3471-05-4

3471-05-4 structure

Name: Anabase
Chemical Name: 3-(2,3,4,5-tetrahydropyridin-6-yl)pyridine
CAS Number: 3471-05-4
Molecular Formula: C₁₀H₁₂N₂
Molecular Weight: 160.22
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2016-05-25 22:00:03
Modify Date: 2025-08-29 15:53:49
Anabaseine, an alkaloid, stimulates a wide variety of animal nicotinic acetylcholine receptors (AChRs), especially the neuromuscular receptors and α7 AChRs[1].

Name	3-(2,3,4,5-tetrahydropyridin-6-yl)pyridine
Synonyms	anabaseine dihydrochloride 2,3'-BIPYRIDINE,3,4,5,6-TETRAHYDRO Anabaseine 3,4,5,6-tetrahydro-2,3'-bipyridine

Description	Anabaseine, an alkaloid, stimulates a wide variety of animal nicotinic acetylcholine receptors (AChRs), especially the neuromuscular receptors and α7 AChRs[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vitro	anabaseine (3.6 μmol/kg; subcutaneous injection) has a peak effect values of 50%, 85%, 62% for acetylcholine, dopamine and norepinephrine, respectively [1][2] . anabaseine act as neuromuscular agonists on the frog rectus abdominis muscle whit a EC50 of 0.25-0.74 μM[1].
References	[1]. [1] Kem W, et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties. Mar Drugs. 2006;4(3):255-273. [2]. [2] Summers KL et al. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Jpn J Pharmacol. 1997 Jun;74(2):139-46.

Density	1.09g/cm3
Boiling Point	263.9ºC at 760mmHg
Molecular Formula	C₁₀H₁₂N₂
Molecular Weight	160.22
Flash Point	113.4ºC
Exact Mass	160.10000
PSA	25.25000
LogP	1.49020
Index of Refraction	1.596

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW1890000

CHEMICAL NAME :: 2,3'-Bipyridine, 3,4,5,6-tetrahydro-

CAS REGISTRY NUMBER :: 3471-05-4

BEILSTEIN REFERENCE NO. :: 0125981

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,684,1976

HS Code	2933399090

81417-95-0

~74%

3471-05-4

Literature: Alberici, Gilles F.; Andrieux, Jean; Adam, Gerard; Plat, Michel M. Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1937 - 1940

60573-68-4

3471-05-4

Literature: Alberici, Gilles F.; Andrieux, Jean; Adam, Gerard; Plat, Michel M. Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1937 - 1940

614-18-6

161564-43-8

3471-05-4

Literature: Shevchenko, Nikolay E.; Vlasov, Katja; Nenajdenko, Valentine G.; Roeschenthaler, Gerd-Volker Tetrahedron, 2011 , vol. 67, # 1 p. 69 - 74

626-55-1

3471-05-4

Literature: Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234

675-20-7

3471-05-4

Literature: Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234

85908-96-9

3471-05-4

Literature: Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234

614-18-6

4252-56-6

141-52-6

71-43-2

Detail

Literature: Spaeth; Mamoli Chemische Berichte, 1936 , vol. 69, p. 757,760 Full Text Show Details Duffield et al. Journal of the American Chemical Society, 1965 , vol. 87, p. 2926,2027 Full Text Show Details Kamimura; Yamamoto Agricultural and Biological Chemistry, 1963 , vol. 27, p. 450,453

614-18-6

4252-56-6

3471-05-4

Literature: Spaeth; Mamoli Chemische Berichte, 1936 , vol. 69, p. 1082,1085

Precursor 9
81417-95-0 60573-68-4 614-18-6 626-55-1
675-20-7 85908-96-9 4252-56-6 141-52-6
71-43-2
DownStream 2
581-50-0 13078-04-1

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2138256-62-7	2137748-59-3
2137748-65-1	2138266-98-3
2138256-78-5	2229280-61-7
2137443-46-8	2137778-32-4
2138267-83-9	2137518-09-1