3615-17-6

3615-17-6 structure

Name: 2-acetamido-2-deoxy-D-mannose
Chemical Name: aldehydo-N-acetyl-D-mannosamine
CAS Number: 3615-17-6
Molecular Formula: C₈H₁₅NO₆
Molecular Weight: 221.20800
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-03-21 08:00:00
Modify Date: 2024-01-13 17:56:16
N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1].N-Acetyl-D-mannosamine (ManNAc) can be metabolized by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP), into ManNAc-6-phosphate and GlcNAc, respectively. N-Acetyl-d-mannosamine (ManNAc) and its derivatives activates hypocretin (HCRT) gene expression in the orexin neurons, providing a potential model for the testing of a therapy for neural disorders[2].

Name	aldehydo-N-acetyl-D-mannosamine
Synonyms	2-Acetamido-2-deoxy-D-mannopyranose Monohydrate 2-acetamido-2-deoxy-D-galacticol N-((2S,3R,4S,5R)-3,4,5,6-Tetrahydroxy-1-oxohexan-2-yl)acetamide GalNAc-ol 2-acetamido-2-deoxygalactitol 2-acetamido-2-deoxy-galactose HPG-Beta2-N1 2-Acetamido-2-deoxy-D-galactitol N-acetyl-galactosaminitol MFCD00136044 D-GalNAc-ol 2-acetamido-2-deoxy-D-mannose N-Acetyl-D-galactosaminitol N-Acetyl-D-mannosamine Monohydrate EINECS 222-790-8 2-acetamido-2-deoxy-D-galacitol

Description	N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1].N-Acetyl-D-mannosamine (ManNAc) can be metabolized by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP), into ManNAc-6-phosphate and GlcNAc, respectively. N-Acetyl-d-mannosamine (ManNAc) and its derivatives activates hypocretin (HCRT) gene expression in the orexin neurons, providing a potential model for the testing of a therapy for neural disorders[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101. [2]. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778.