2-acetamido-2-deoxy-D-mannose

Modify Date: 2024-01-13 17:56:16

2-acetamido-2-deoxy-D-mannose structure	Common Name	2-acetamido-2-deoxy-D-mannose
	CAS Number	3615-17-6	Molecular Weight	221.20800
	Density	1.423g/cm3	Boiling Point	636.4ºC at 760mmHg
	Molecular Formula	C₈H₁₅NO₆	Melting Point	205ºC
	MSDS	N/A	Flash Point	338.7ºC

Use of 2-acetamido-2-deoxy-D-mannose

N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1].N-Acetyl-D-mannosamine (ManNAc) can be metabolized by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP), into ManNAc-6-phosphate and GlcNAc, respectively. N-Acetyl-d-mannosamine (ManNAc) and its derivatives activates hypocretin (HCRT) gene expression in the orexin neurons, providing a potential model for the testing of a therapy for neural disorders[2].

Name	aldehydo-N-acetyl-D-mannosamine
Synonym	More Synonyms

Description	N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1].N-Acetyl-D-mannosamine (ManNAc) can be metabolized by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP), into ManNAc-6-phosphate and GlcNAc, respectively. N-Acetyl-d-mannosamine (ManNAc) and its derivatives activates hypocretin (HCRT) gene expression in the orexin neurons, providing a potential model for the testing of a therapy for neural disorders[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101. [2]. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778.

Description

Related Catalog

Research Areas >> Neurological Disease

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101.

[2]. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778.

Density	1.423g/cm3
Boiling Point	636.4ºC at 760mmHg
Melting Point	205ºC
Molecular Formula	C₈H₁₅NO₆
Molecular Weight	221.20800
Flash Point	338.7ºC
Exact Mass	221.09000
PSA	119.25000
Index of Refraction	1.575
Storage condition	-20°C Freezer

2-acetamido-2-deoxy-D-mannose MSDS(Chinese)

Precursor 4
CAS#:110-86-1 Pyridine CAS#:7512-17-6 N-acetyl-α-D-gl... CAS#:373-02-4 Nickel-acetic a... CAS#:131-48-6 N-Acetylneurami...
DownStream 1
CAS#:3063-71-6 Cytidine 5'-mon...