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66036-77-9

66036-77-9 structure
66036-77-9 structure
  • Name: H-D-Arg(NO2)-OH
  • Chemical Name: (R)-2-Amino-5-(3-nitroguanidino)pentanoic acid
  • CAS Number: 66036-77-9
  • Molecular Formula: C6H13N5O4
  • Molecular Weight: 219.199
  • Catalog: Biochemical Amino acids and their derivatives Arginine derivatives
  • Create Date: 2018-09-21 14:02:50
  • Modify Date: 2024-01-10 20:09:17
  • N'-Nitro-D-arginine (NOLA), a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) [1].
Name (R)-2-Amino-5-(3-nitroguanidino)pentanoic acid
Synonyms MFCD00066013
L-Ornithine, N-[(E)-imino(nitroamino)methyl]-
D-Ornithine, N-[amino(nitroamino)methylene]-, (E)-
N-ω-NITRO-L-ARGININE
(E)-N-[Amino(nitroamino)methylene]-D-ornithine
N'-Nitro-D-arginine
H-Arg(NO2)-OH
L-Ornithine, N5-(imino(nitroamino)methyl)-
N-(N-Nitrocarbamimidoyl)-L-ornithine
H-D-Arg(NO2)-OH
Ng-Nitro-D-arginine
Description N'-Nitro-D-arginine (NOLA), a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) [1].
Related Catalog
In Vivo N'-Nitro-D-arginine (NOLA) (40 mg/ kg) produces a significant increase in systolic blood pressure in the chronic, awake, instrumented sheep model[1].
References

[1]. C K Narkowicz, et al. Delayed recovery from NG-nitro-L-arginine in the conscious sheep. Clin Exp Pharmacol Physiol. 1991 Dec;18(12):843-6.
Density 1.7±0.1 g/cm3
Boiling Point 462.4±55.0 °C at 760 mmHg
Melting Point >220ºC
Molecular Formula C6H13N5O4
Molecular Weight 219.199
Flash Point 233.5±31.5 °C
Exact Mass 219.096756
PSA 157.05000
LogP -0.79
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.638
Storage condition Store at RT.
Material Safety Data Sheet
Section1. Identification of the substance
Product Name: H-D-Arg(No2)-OH
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
Section3. Composition/information on ingredients.
Ingredient name:H-D-Arg(No2)-OH
CAS number:66036-77-9
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C6H13N5O4
Molecular weight:219.2
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A
Hazard Codes Xn
Risk Phrases 22-36/37/38
Safety Phrases 26-36
HS Code 2925290090
Precursor  0

DownStream  1

HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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