66634-44-4

66634-44-4 structure

66634-44-4 structure

Name: methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate,hydrochloride
Chemical Name: methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate,hydrochloride
CAS Number: 66634-44-4
Molecular Formula: C₂₁H₂₇ClN₂O₃
Molecular Weight: 390.90400
Create Date: 2018-09-22 11:22:17
Modify Date: 2024-01-13 08:52:15

Name	methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate,hydrochloride
Synonyms	Prestwick_751 Rauhimbine 17\|A-Hydroxyyohimban-16\|A-carboxylic acid methyl ester EINECS 266-430-8 17alpha-Hydroxyyohimban-16beta-carboxylic acid methyl ester MFCD00064554 Chlorhydrate de corynanthine

Molecular Formula	C₂₁H₂₇ClN₂O₃
Molecular Weight	390.90400
Exact Mass	390.17100
PSA	65.56000
LogP	3.38700

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZG1025000

CHEMICAL NAME :: Yohimban-16-beta-carboxylic acid, 17-alpha-hydroxy-, methyl ester, hydrochloride

CAS REGISTRY NUMBER :: 66634-44-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H26-N2-O3.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 50,241,1935

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 146,1042,1952