1312005-62-1
1312005-62-1 structure
- Name: YF-2 hydrochloride
- Chemical Name: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy ]-6-ethoxy-benzamide,hydrochloride
- CAS Number: 1312005-62-1
- Molecular Formula: C20H23Cl2F3N2O3
- Molecular Weight: 467.30900
- Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
- Create Date: 2017-01-13 00:41:30
- Modify Date: 2024-01-07 11:18:59
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YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].
| Name | N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy ]-6-ethoxy-benzamide,hydrochloride |
|---|
| Description | YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1]. |
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| Related Catalog | |
| Target |
CBP:2.75 μM (EC50) PCAF:29.04 μM (EC50) GCN5:49.31 μM (EC50) |
| In Vitro | YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1]. |
| In Vivo | YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1]. |
| References |
[1]. FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1. |
| Molecular Formula | C20H23Cl2F3N2O3 |
|---|---|
| Molecular Weight | 467.30900 |
| Exact Mass | 466.10400 |
| PSA | 54.29000 |
| LogP | 6.13620 |
| Storage condition | 2-8℃ |