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  • DC Chemicals Limited
  • China
  • Product Name: Clazosentan
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

180384-56-9

180384-56-9 structure
180384-56-9 structure

Name N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methylpyridine-2-sulfonamide
Synonyms UNII-3DRR0X4728
Clazosentan
Description Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5].
Related Catalog
In Vitro Clazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries[3]. Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3[5].
In Vivo Clazosentan (10 μM, 0.05 mL/kg, intracisternal injection) inhibits the contractile responses to ET-1 in rats[2]. Clazosentan (10 mg/kg, s.c.) inhibits IL-33-induced hypernociception in mice[4]. Animal Model: Rats[2] Dosage: 10 μM, 0.05 mL/kg Administration: Intracisternal injection Result: Inhibited the contractile responses to ET-1, without preventing SAH-induced upregulation of ET receptors in cerebral arteries.
Density 1.485g/cm3
Boiling Point 754.5ºC at 760 mmHg
Molecular Formula C25H23N9O6S
Molecular Weight 577.57200
Flash Point 410.1ºC
Exact Mass 577.14900
PSA 208.49000
LogP 3.54870
Vapour Pressure 6.34E-24mmHg at 25°C
Index of Refraction 1.649