92761-26-7

92761-26-7 structure

Name: ecamsule
Chemical Name: Ecamsule
CAS Number: 92761-26-7
Molecular Formula: C₂₈H₃₄O₈S₂
Molecular Weight: 562.695
Catalog: analytical chemistry Standard Volatile Organic Compounds (VOCs)
Create Date: 2018-07-08 17:34:40
Modify Date: 2024-01-02 12:09:56
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2].

Name	Ecamsule
Synonyms	3,3'-(1,4-Phenylenedimethylidyne)bis[7,7-dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-methanesulfonic Acid] Mexoryl SX 3,3'-(1,4-Phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid) Terephthalylidene-3,3'-dicamphor-10,10'-disulfonic Acid (1,4-Phenylene bis{(Z)methylylidene[(3Z)-7,7-dimethyl-2-oxobicyclo [2.2.1]hept-1-yl-3-ylidene]})dimethanesulfonic acid (1,4-Phenylenebis{(Z)methylylidene[(3Z)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl-3-ylidene]})dimethanesulfonic acid Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 3,3'-[1,4-phenylenedi(Z)methylidyne]bis[7,7-dimethyl-2-oxo-, (3Z)-

Description	Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1]. Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment[1]. . Ecamsule counteractes UV and AAPH induced ROS-formation[1]. .The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%[1]. . Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells[1].
References	[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244. [2]. DeLeo VA, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H318
Precautionary Statements	P280-P305 + P351 + P338 + P310
Hazard Codes	Xi: Irritant;
Risk Phrases	41
Safety Phrases	26-39
RIDADR	NONH for all modes of transport