Shanghai Nianxing Industrial Co., Ltd
China
Product Name: QX 222
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: QX-222 chloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

5369-00-6

5369-00-6 structure

5369-00-6 structure

Name: QX-222 chloride
Chemical Name: 2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoethanaminium c hloride
CAS Number: 5369-00-6
Molecular Formula: C₁₃H₂₁ClN₂O
Molecular Weight: 256.77200
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2017-09-26 01:04:53
Modify Date: 2025-08-26 23:52:36
QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker[1][2][3].

Name	2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoethanaminium c hloride

Description	QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
In Vitro	Twelve minutes after external application of 500 μM QX222 chloride, μ1 IP-Loop to Heart Sequence (μ1-Y401C) results in a significant block compared with μ1-WT (WT, 14.2±1.6% block, n = 8; Y401C, 45.2±3.6% block, n = 9; P < 0.001)[1].
In Vivo	QX-222 (10 mg/kg; intravenous infusion 7 days) chloride reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats[2].
References	[1]. A Sunami, et al. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2326-31. [2]. Qingmin Chen, et al. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. J Pain. 2004 Jun;5(5):281-9. [3]. J A Flatman, et al. Reversibility of Ia EPSP investigated with intracellularly iontophoresed QX-222. J Neurophysiol. 1982 Aug;48(2):419-30.

Molecular Formula	C₁₃H₂₁ClN₂O
Molecular Weight	256.77200
Exact Mass	256.13400
PSA	35.42000
LogP	3.27210

Hazard Codes	Xi

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.