101238-54-4

101238-54-4 structure

Name: Levoemopamil Hydrochloride
Chemical Name: (2S)-5-[methyl(2-phenylethyl)amino]-2-phenyl-2-propan-2-ylpentanenitrile,hydrochloride
CAS Number: 101238-54-4
Molecular Formula: C₂₃H₃₁ClN₂
Molecular Weight: 370.95900
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2017-11-24 15:10:18
Modify Date: 2024-01-11 17:47:06
Levemopamil hydrochloride is a blood-brain barrier penetrable calcium channel blocker and a 5-HT2 antagonist. Levemopamil hydrochloride can be used for temporary occlusion and neurological disease research[1].

Name	(2S)-5-[methyl(2-phenylethyl)amino]-2-phenyl-2-propan-2-ylpentanenitrile,hydrochloride
Synonyms	(2S)-5-[methyl(phenethyl)amino]-2-phenyl-2-propan-2-ylpentanenitrile hydrochloride Levemopamil hydrochloride

Description	Levemopamil hydrochloride is a blood-brain barrier penetrable calcium channel blocker and a 5-HT2 antagonist. Levemopamil hydrochloride can be used for temporary occlusion and neurological disease research[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vivo	Levemopamil hydrochloride (30 mg/kg；腹腔注射，1 次) 可调节双侧颈动脉阻尼 (BCCA) 过程，降低大鼠脑低血症引起的空间记忆障碍[1]。 Animal Model: Male Han-Wistar rats with bilateral damping of carotid arteries (BCCA)[1] Dosage: 30 mg/kg Administration: Intraperitoneal injection; 30 mg/kg, once Result: Showed no effect on GABA or ACh content in either BCCA or sham-operated control rats. Significantly increased swimming speed of BCCA rats in swimming test. Prevented the increasing of escape latency to reach the hidden platform.
References	[1]. Heim C, et al. Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats. Pharmacol Biochem Behav. 1994 Jul;48(3):613-9.