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120205-50-7

120205-50-7 structure
120205-50-7 structure
  • Name: (2R,3R)-BOC-dolaproine
  • Chemical Name: (2R,3R)-3-((S)-1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid
  • CAS Number: 120205-50-7
  • Molecular Formula: C14H25NO5
  • Molecular Weight: 287.352
  • Catalog: Research Areas Cancer
  • Create Date: 2018-12-21 16:48:29
  • Modify Date: 2024-01-02 18:13:19
  • N-Boc-dolaproine (Dap) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].

Name (2R,3R)-3-((S)-1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid
Synonyms (2R,3R)-3-Methoxy-2-methyl-3-[(2S)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-2-pyrrolidinyl]propanoic acid
2-Pyrrolidinepropanoic acid, 1-[(1,1-dimethylethoxy)carbonyl]-β-methoxy-α-methyl-, (αR,βR,2S)-
(2R,3R)-3-methoxy-2-methyl-3-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]propanoic acid
((2R,3R)-3-((S)-1-(tertbutoxycarbonyl)pyrrolidin-2-yl)-3-Methoxy-2-Methylpropanoic acid
Description N-Boc-dolaproine (Dap) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].
Related Catalog
References

[1]. Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44(5): 937-940.

Density 1.1±0.1 g/cm3
Boiling Point 397.8±17.0 °C at 760 mmHg
Molecular Formula C14H25NO5
Molecular Weight 287.352
Flash Point 194.4±20.9 °C
Exact Mass 287.173279
PSA 76.07000
LogP 1.36
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.490