479347-86-9
479347-86-9 structure
- Name: NBQX disodium salt
- Chemical Name: disodium,6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate
- CAS Number: 479347-86-9
- Molecular Formula: C12H6N4Na2O6S
- Molecular Weight: 380.244
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2017-04-30 09:17:00
- Modify Date: 2024-01-09 15:57:35
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NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1].
| Name | disodium,6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate |
|---|---|
| Synonyms |
Disodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate
Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, sodium salt (1:2) FG9202 disodium NBQX disodium FG 9202 disodium salt hydrate NBQX,Disodium Salt |
| Description | NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1]. |
|---|---|
| Related Catalog | |
| Target |
AMPA receptor[1] |
| In Vitro | NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1]. |
| In Vivo | NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2]. NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1]. Animal Model: Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2] Dosage: 20 mg/kg Administration: IP; for 3 days Result: Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats. |
| References |
| Molecular Formula | C12H6N4Na2O6S |
|---|---|
| Molecular Weight | 380.244 |
| Exact Mass | 379.980347 |
| PSA | 186.26000 |
| LogP | 3.93050 |