25743-12-8
25743-12-8 structure
- Name: NH-bis-PEG3
- Chemical Name: 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethylamino]ethoxy]ethoxy]ethanol
- CAS Number: 25743-12-8
- Molecular Formula: C12H27NO6
- Molecular Weight: 281.34600
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2016-01-29 05:40:25
- Modify Date: 2024-01-09 12:20:04
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NH-bis-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethylamino]ethoxy]ethoxy]ethanol |
|---|---|
| Synonyms | 3,6,12,15-Tetraoxa-9-azaheptadecane-1,17-diol |
| Description | NH-bis-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C12H27NO6 |
|---|---|
| Molecular Weight | 281.34600 |
| Exact Mass | 281.18400 |
| PSA | 89.41000 |
|
~87%
25743-12-8 |
| Literature: Iqbal, Mudassir; Huskens, Jurriaan; Sypula, Michal; Modolo, Giuseppe; Verboom, Willem New Journal of Chemistry, 2011 , vol. 35, # 11 p. 2591 - 2600 |
|
~56%
25743-12-8 |
| Literature: Maeda, Hirokazu; Furuyoshi, Shigeo; Nakatsuji, Yohji; Okahara, Mitsuo Tetrahedron, 1982 , vol. 38, # 22 p. 3359 - 3362 |
|
~%
25743-12-8 |
| Literature: Iqbal, Mudassir; Huskens, Jurriaan; Sypula, Michal; Modolo, Giuseppe; Verboom, Willem New Journal of Chemistry, 2011 , vol. 35, # 11 p. 2591 - 2600 |
|
~%
25743-12-8 |
| Literature: Maeda, Hirokazu; Furuyoshi, Shigeo; Nakatsuji, Yohji; Okahara, Mitsuo Tetrahedron, 1982 , vol. 38, # 22 p. 3359 - 3362 |
| Precursor 3 | |
|---|---|
| DownStream 1 | |
