NH-bis-PEG3

Modify Date: 2024-01-09 12:20:04

NH-bis-PEG3 structure	Common Name	NH-bis-PEG3
	CAS Number	25743-12-8	Molecular Weight	281.34600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₂₇NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NH-bis-PEG3

NH-bis-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethylamino]ethoxy]ethoxy]ethanol
Synonym	More Synonyms

Description	NH-bis-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₂H₂₇NO₆
Molecular Weight	281.34600
Exact Mass	281.18400
PSA	89.41000

N/A

CAS#:1350558-97-2

~87%

NH-bis-PEG3

CAS#:25743-12-8

Literature: Iqbal, Mudassir; Huskens, Jurriaan; Sypula, Michal; Modolo, Giuseppe; Verboom, Willem New Journal of Chemistry, 2011 , vol. 35, # 11 p. 2591 - 2600

2-[2-(2-Aminoet...

CAS#:6338-55-2

2-(2-(2-Chloroe...

CAS#:5197-62-6

~56%

NH-bis-PEG3

CAS#:25743-12-8

Literature: Maeda, Hirokazu; Furuyoshi, Shigeo; Nakatsuji, Yohji; Okahara, Mitsuo Tetrahedron, 1982 , vol. 38, # 22 p. 3359 - 3362

2-(2-(2-Chloroe...

CAS#:5197-62-6

NH-bis-PEG3

CAS#:25743-12-8

Literature: Iqbal, Mudassir; Huskens, Jurriaan; Sypula, Michal; Modolo, Giuseppe; Verboom, Willem New Journal of Chemistry, 2011 , vol. 35, # 11 p. 2591 - 2600