- GL Biochem (Shanghai) Ltd.
- China
- Product Name: 3S-3,4-Propano-2,3-dihydropyrido3,2-f1,4oxazepine-5(4H)-one
- Price: ￥Inquiry/1kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Jackie Yang
- DC Chemicals Limited
- China
- Product Name: Org-26576
- Price: $350.0/100mg $700.0/250mg $1400.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Nanjing Peptide Biotech Ltd
- China
- Product Name: 3S-3,4-Propano-2,3-dihydropyrido3,2-f1,4oxazepine-5(4H)-one
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
1026791-61-6
1026791-61-6 structure
- Name: Org-26576
- Chemical Name: unii-0h1idr8z4f
- CAS Number: 1026791-61-6
- Molecular Formula: C11H12N2O2
- Molecular Weight: 204.22500
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2016-12-09 14:16:13
- Modify Date: 2024-01-02 22:07:43
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Org 26576 is a AMPA receptor positive allosteric modulator.
| Name | unii-0h1idr8z4f |
|---|---|
| Synonyms | Org-26576 |
| Description | Org 26576 is a AMPA receptor positive allosteric modulator. |
|---|---|
| Related Catalog | |
| In Vitro | Org 26576 represents structurally a distinct chemical series derived from the first generation ampakine CX516 and displays 10-30 fold greater potency when compared to CX516 in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 μM in rat hippocampal primary cultured neurons. Org 26576 demonstrates selectivity for AMPA receptors when tested at 10 μM against >60 molecular targets including G-Protein Coupled Receptors, ion channels and kinases[1]. |
| In Vivo | Org 26576 (1 mg/kg) produces significant increases in the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus and CA3 subfield of the hippocampus in mice[1]. Chronic administration of Org 26576 increases progenitor cell proliferation in dentate gyrus (approximately 40%) and in prelimbic cortex (approximately 35%) at the 10-mg/kg dosage. Cells born in response to chronic Org 26576 in dentate gyrus exhibits increased rates of survival (approximately 30%) with the majority of surviving cells expressing a neuronal phenotype[2]. AMPA receptor potentiation by Org 26576 exerts a positive modulatory influence on brain derived neurotrophic factor (BDNF) expression during ongoing neuronal activity. Total BDNF mRNA levels are significantly increased in the hippocampus of animals exposed to the combination of Org 26576 and stress[3]. |
| Animal Admin | Rats: Saline and Org 26576 (10 mg/kg) are administered, by intraperitoneal injection, 25 min before acute swim stress. Briefly, rats are subjected to a swim stress session for 5 min and sacrificed by decapitation 15 min after the end of the swim session. Brain regions are immediately dissected, frozen on dry ice and stored at -80°C[3]. Mice: Org 26576 (0.1, 1, 10 mg/kg) and Org 24448 (3, 10, 30 mg/kg) or vehicle (5% Mulgofenesaline) are administered intraperitoneally (i.p.) 10 min prior to the administration of the 14C-2-deoxyglucose. All drugs/vehicle are administered in the contralateral side of the abdomen to the 14C-2-deoxyglucose (2-DG) i.p. injection. A separate group of animals is also administered the AMPA receptor antagonist NBQX. NBQX (10 mg/kg) is injected either alone or 10 min prior to the administration of Org 26576 (10 mg/kg i.p.), Org 24448 (10 mg/kg i.p.) or vehicle (5% Mulgofenesaline i.p.). For each drug dose administered nZ5e7. The behavioural effects of all drugs administered are monitored throughout the entirety of procedure, and any alterations in behaviour noted[1]. |
| References |
| Molecular Formula | C11H12N2O2 |
|---|---|
| Molecular Weight | 204.22500 |
| Exact Mass | 204.09000 |
| PSA | 42.43000 |
| LogP | 1.01650 |
| Storage condition | 2-8℃ |