51833-69-3

51833-69-3 structure

Name: (Sar1)-Angiotensin II
Chemical Name: angiotensin II
CAS Number: 51833-69-3
Molecular Formula: C₄₉H₇₁N₁₃O₁₀
Molecular Weight: 1002.17000
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2016-07-10 19:13:53
Modify Date: 2024-01-02 23:53:25
(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes[1][2][3].

Name	angiotensin II
Synonyms	(Sar1)-Angiotensin II

Description	(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
In Vitro	(Sar1)-Angiotensin II (1 μM/day; 9 d) increases the total protein content in embryonic chick myocytes by 18.5, 26.2, and 22.2% at 5, 7, and 9 days, respectively[2]. (Sar1)-Angiotensin II binds to brain membrane-rich particles in cynomolgus monkey brain, with a Kd of 2.7 nM[3].
References	[1]. Matsoukas JM, et, al. Differences in backbone structure between angiotensin II agonists and type I antagonists. J Med Chem. 1995 Nov 10;38(23):4660-9. [2]. Aceto JF, et, al. [Sar1]angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am J Physiol. 1990 Mar;258(3 Pt 2):H806-13. [3]. Millan MA, et, al. Distribution of angiotensin II receptors in the brain of nonhuman primates. Peptides. Mar-Apr 1990;11(2):243-53.