58816-69-6
58816-69-6 structure
- Name: SB297006
- Chemical Name: sb 297006
- CAS Number: 58816-69-6
- Molecular Formula: C18H18N2O5
- Molecular Weight: 342.34600
- Catalog: Research Areas Neurological Disease
- Create Date: 2017-05-15 00:32:59
- Modify Date: 2026-07-15 12:46:02
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SB297006 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.
| Name | sb 297006 |
|---|---|
| Synonyms |
SB297006, 10 mM in DMSO
(S)-Ethyl 2-benzamido-3-(4-nitrophenyl)propanoate inhibit,Inhibitor,CCR,SB297006,CC chemokine rector,SB-297006 N-Benzoyl-4-nitro-L-phenylalanine ethyl ester SB 297006, CCR3 antagonist N-Benzoyl-4-nitroaniline ethyl ester n-benzoyl-4-nitroaniline ethyl ester ethyl (2S)-2-(benzoylaMino)-3-(4-nitrophenyl)propanoate L-Phenylalanine, N-benzoyl-4-nitro-, ethyl ester |
| Description | SB297006 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells. |
|---|---|
| Related Catalog | |
| Target |
CCR3[1] |
| In Vitro | SB297006 is a CCR3 antagonist, significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells (NPCs) at 100 μM[1]. |
| Cell Assay | To evaluate CCR3 blocking, neural progenitor cells (NPCs) are incubated with the CCR3 antagonist SB297006 (100 μM) for 30 minutes and then stimulated with CCL11 (2 μg/mL). After 3 days of culture, NPCs are subjected to CCK-8 assays[1]. |
| References |
| Melting Point | 121 °C |
|---|---|
| Molecular Formula | C18H18N2O5 |
| Molecular Weight | 342.34600 |
| Exact Mass | 342.12200 |
| PSA | 101.22000 |
| LogP | 3.41310 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P273 |
| RIDADR | UN 3077 9 / PGIII |
| Precursor 0 | |
|---|---|
| DownStream 1 | |
