99011-78-6
99011-78-6 structure
- Name: Imiquimod (hydrochloride)
- Chemical Name: 1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-, hydrochloride
- CAS Number: 99011-78-6
- Molecular Formula: C14H17ClN4
- Molecular Weight: 276.76500
- Catalog: Signaling Pathways Autophagy Autophagy
- Create Date: 2016-01-12 12:53:25
- Modify Date: 2024-01-11 20:57:37
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Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7agonist.
| Name | 1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-, hydrochloride |
|---|---|
| Synonyms |
Imiquimod (hydrochloride)
1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-, monohydrochloride Imiquimod hydrochloride |
| Description | Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7agonist. |
|---|---|
| Related Catalog | |
| Target |
Toll-like receptor 7 |
| In Vivo | In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secretecytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1]. |
| References |
[1]. Bilu D, et al. Imiquimod: modes of action. Br J Dermatol. 2003 Nov;149 Suppl 66:5-8. |
| Molecular Formula | C14H17ClN4 |
|---|---|
| Molecular Weight | 276.76500 |
| Exact Mass | 276.11400 |
| PSA | 56.73000 |
| LogP | 4.20590 |