171714-84-4
171714-84-4 structure
- Name: Darusentan
- Chemical Name: (2S)-2-(4,6-dimethoxypyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid
- CAS Number: 171714-84-4
- Molecular Formula: C22H22N2O6
- Molecular Weight: 410.420
- Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
- Create Date: 2018-08-23 08:01:32
- Modify Date: 2024-01-10 21:55:05
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Darusentan is a selective endothelin A (ETA) receptor antagonist. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki=13 nM[1].
| Name | (2S)-2-(4,6-dimethoxypyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid |
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| Synonyms |
Benzenepropanoic acid, α-[(4,6-dimethoxy-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (αS)-
(+)-(S)-2-(4,6-dimethoxypyrimidine-2-yloxy)-3-methoxy-3,3-diphenylpropionic acid (2S)-2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid HMR-4005 henyl-,(S) Darusentan (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl-propionic acid (2S)-2-[(4,6-Dimethoxy-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid |
| Description | Darusentan is a selective endothelin A (ETA) receptor antagonist. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki=13 nM[1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 587.3±60.0 °C at 760 mmHg |
| Molecular Formula | C22H22N2O6 |
| Molecular Weight | 410.420 |
| Flash Point | 309.0±32.9 °C |
| Exact Mass | 410.147797 |
| PSA | 100.00000 |
| LogP | 6.90 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.583 |
| Hazard Codes | Xn |
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