23197-98-0
23197-98-0 structure
- Name: 8-Br-GTP
- Chemical Name: [[(2R,3S,4R,5R)-5-(2-amino-1-bromo-6-oxopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
- CAS Number: 23197-98-0
- Molecular Formula: C10H15BrN5O14P3
- Molecular Weight: 602.07600
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2016-06-20 14:56:26
- Modify Date: 2025-08-25 11:45:12
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8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1].
| Name | [[(2R,3S,4R,5R)-5-(2-amino-1-bromo-6-oxopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
|---|---|
| Synonyms |
8-Bromo-GTP
8-bromoguanosine triphosphate 8-bromoguanosine 5'-triphosphate |
| Description | 8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 8-Br-GTP inhibits FtsZ polymerization but does not affect tubulin polymerization.8-Br-GTP has two stable orientations of the base toward the sugar: anti and syn. 8-Br-GTP shows preference for the syn conformation (population ~90%)[1][2]. |
| References |
| Density | 2.89g/cm3 |
|---|---|
| Boiling Point | 1354.2ºC at 760 mmHg |
| Molecular Formula | C10H15BrN5O14P3 |
| Molecular Weight | 602.07600 |
| Flash Point | 772.8ºC |
| Exact Mass | 600.90100 |
| PSA | 328.53000 |
| Vapour Pressure | 0mmHg at 25°C |
|
~68%
23197-98-0 |
| Literature: Gordeeva, L. S.; Kaminskii, Yu. L.; Rumyantseva, L. N.; Patokina, N. A.; Korsakova, N. A.; et al. Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 729 - 733 Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 771 - 776 |
| Precursor 1 | |
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| DownStream 0 | |