23197-98-0

23197-98-0 structure

Name: 8-Br-GTP
Chemical Name: [[(2R,3S,4R,5R)-5-(2-amino-1-bromo-6-oxopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
CAS Number: 23197-98-0
Molecular Formula: C₁₀H₁₅BrN₅O₁₄P₃
Molecular Weight: 602.07600
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-06-20 14:56:26
Modify Date: 2024-01-02 16:26:18
8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1].

Name	[[(2R,3S,4R,5R)-5-(2-amino-1-bromo-6-oxopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Synonyms	8-Bromo-GTP 8-bromoguanosine triphosphate 8-bromoguanosine 5'-triphosphate

Description	8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	8-Br-GTP inhibits FtsZ polymerization but does not affect tubulin polymerization.8-Br-GTP has two stable orientations of the base toward the sugar: anti and syn. 8-Br-GTP shows preference for the syn conformation (population ~90%)[1][2].
References	[1]. Tilman Läppchen, et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry. 2005 May 31;44(21):7879-84. [2]. Jozef Hritz, et al. Optimization of replica exchange molecular dynamics by fast mimicking. J Chem Phys. 2007 Nov 28;127(20):204104.

Density	2.89g/cm3
Boiling Point	1354.2ºC at 760 mmHg
Molecular Formula	C₁₀H₁₅BrN₅O₁₄P₃
Molecular Weight	602.07600
Flash Point	772.8ºC
Exact Mass	600.90100
PSA	328.53000
Vapour Pressure	0mmHg at 25°C

79787-02-3

~68%

23197-98-0

Literature: Gordeeva, L. S.; Kaminskii, Yu. L.; Rumyantseva, L. N.; Patokina, N. A.; Korsakova, N. A.; et al. Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 729 - 733 Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 771 - 776

Precursor 1
79787-02-3
DownStream 0

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