8-Br-GTP

Modify Date: 2024-01-02 16:26:18

8-Br-GTP structure	Common Name	8-Br-GTP
	CAS Number	23197-98-0	Molecular Weight	602.07600
	Density	2.89g/cm3	Boiling Point	1354.2ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₅BrN₅O₁₄P₃	Melting Point	N/A
	MSDS	N/A	Flash Point	772.8ºC

Use of 8-Br-GTP

8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1].

Name	[[(2R,3S,4R,5R)-5-(2-amino-1-bromo-6-oxopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Synonym	More Synonyms

Description	8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	8-Br-GTP inhibits FtsZ polymerization but does not affect tubulin polymerization.8-Br-GTP has two stable orientations of the base toward the sugar: anti and syn. 8-Br-GTP shows preference for the syn conformation (population ~90%)[1][2].
References	[1]. Tilman Läppchen, et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry. 2005 May 31;44(21):7879-84. [2]. Jozef Hritz, et al. Optimization of replica exchange molecular dynamics by fast mimicking. J Chem Phys. 2007 Nov 28;127(20):204104.

Density	2.89g/cm3
Boiling Point	1354.2ºC at 760 mmHg
Molecular Formula	C₁₀H₁₅BrN₅O₁₄P₃
Molecular Weight	602.07600
Flash Point	772.8ºC
Exact Mass	600.90100
PSA	328.53000
Vapour Pressure	0mmHg at 25°C

Guanosine 5'-(t...

CAS#:79787-02-3

~68%

8-Br-GTP

CAS#:23197-98-0

Literature: Gordeeva, L. S.; Kaminskii, Yu. L.; Rumyantseva, L. N.; Patokina, N. A.; Korsakova, N. A.; et al. Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 729 - 733 Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 771 - 776

Precursor 1
CAS#:79787-02-3 Guanosine 5'-(t...
DownStream 0

8-Bromo-GTP

8-bromoguanosine triphosphate

8-bromoguanosine 5'-triphosphate

DC Chemicals Limited
China
Product Name: 8-Br-GTP
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 8-bromoguanosine triphosphate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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8-Br-GTP

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