2719-05-3
- Name: 4,4'-diacetamidodiphenylmethane
- Chemical Name: 4,4'-diacetamidodiphenylmethane
- CAS Number: 2719-05-3
- Molecular Formula: C17H18N2O2
- Molecular Weight: 282.337
- Catalog: Research Areas Others
- Create Date: 2018-02-20 08:00:00
- Modify Date: 2024-01-03 17:02:13
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FH1(BRDK4477) is a small molecule that can enhance the functions of cultured hepatocytes.IC50 value:Target: In vitro: FH1(BRD-K4477) enhances hepatocyte functions, and promotes the maturation of well-differentiated cultures of iHeps, which potentially alleviates a major obstacle to the use of iPS cells as a renewable source of functional human hepatocytes.
| Name | 4,4'-diacetamidodiphenylmethane |
|---|---|
| Synonyms |
N,N'-AcetylMDA
4.4'-Bis-acetamino-diphenylmethan N,N'-diacetyl-4,4'-methylenedianiline 4,4'-diacetoamino-diphenylmethane N,N'-(Methylenedi-4,1-phenylene)diacetamide 4',4''-METHYLENEBIS(ACETANILIDE) N1-{4-[4-(acetylamino)benzyl]phenyl}acetamide 4,4'-Diacetyldiaminodiphenylmethan Acetamide, N,N'-(methylenedi-4,1-phenylene)bis- N-[4-[(4-Acetamidophenyl)Methyl]Phenyl]Acetamide BRD-K4477 FH1 |
| Description | FH1(BRDK4477) is a small molecule that can enhance the functions of cultured hepatocytes.IC50 value:Target: In vitro: FH1(BRD-K4477) enhances hepatocyte functions, and promotes the maturation of well-differentiated cultures of iHeps, which potentially alleviates a major obstacle to the use of iPS cells as a renewable source of functional human hepatocytes. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 564.6±43.0 °C at 760 mmHg |
| Molecular Formula | C17H18N2O2 |
| Molecular Weight | 282.337 |
| Flash Point | 217.8±28.3 °C |
| Exact Mass | 282.136841 |
| PSA | 58.20000 |
| LogP | 1.93 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.635 |
| Storage condition | -20℃ |
| Symbol |
GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H400 |
| Precautionary Statements | P273 |
| Risk Phrases | R22;R40 |
| Safety Phrases | S22-S36/37 |
| RIDADR | UN 3077 9 / PGIII |
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~84%
2719-05-3 |
| Literature: Kimura, Tsutomu; Hosokawa-Muto, Junji; Kamatari, Yuji O.; Kuwata, Kazuo Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1502 - 1507 |
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~86%
2719-05-3 |
| Literature: Barbero, Margherita; Bazzi, Stefano; Cadamuro, Silvano; Dughera, Stefano; Ghigo, Giovanni European Journal of Organic Chemistry, 2009 , # 25 p. 4346 - 4351 |
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| Literature: Journal of the American Chemical Society, , vol. 68, p. 2600 Journal of the American Chemical Society, , vol. 3, p. 1502,1503 |
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~59%
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| Literature: Mashraqui, Sabir H.; Nirantar, Swati S.; Biswas, Maloyesh M. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 12 p. 1102 - 1104 |
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| Literature: Helvetica Chimica Acta, , vol. 12, p. 868 Journal of the American Chemical Society, , vol. 47, p. 2615 |
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| Literature: Helvetica Chimica Acta, , vol. 12, p. 868 |
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| Literature: Journal of the Chemical Society, , p. 1886,1892 |
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| Literature: Justus Liebigs Annalen der Chemie, , vol. 283, p. 161 Chemische Berichte, , vol. 25, p. 304 |
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2719-05-3
Detail
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| Literature: Journal of the Chemical Society, , p. 1886,1892 |
![N-[4-[(4-acetamido-3-bromophenyl)methyl]-2-bromophenyl]acetamide structure](https://image.chemsrc.com/caspic/466/184170-01-2.png)
![4-[(4-amino-3-bromo-phenyl)methyl]-2-bromo-aniline structure](https://image.chemsrc.com/caspic/033/5329-22-6.png)