87096-84-2

87096-84-2 structure

Name	Neuromedin B (porcine)
Synonyms	GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 ACOH 5H2O NEUROMEDIN B,PORCINE GNLWATGHFM-NH2 Gly-L-Asn-L-Leu-L-Trp-L-Ala-L-Thr-Gly-L-His-L-Phe-L-Met-NH2 H-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 NEUROMEDIN B,PORCINE MAMMALIAN BOMBESIN-LI neuromedin-B Neuromedin B

Description	Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Peptides
In Vitro	Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC50) is only 5% of BN (EC50 of BN/EC50 of NMB) and about 10% of GRP (EC50 of GRP/ EC50 of NMB)[1].
In Vivo	Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively[1].
References	[1]. Ohki-Hamazaki H. Neuromedin B. Prog Neurobiol. 2000 Oct;62(3):297-312.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3.0