128312-51-6
128312-51-6 structure
- Name: Cinalukast
- Chemical Name: cinalukast
- CAS Number: 128312-51-6
- Molecular Formula: C23H28N2O3S
- Molecular Weight: 412.54500
- Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
- Create Date: 2018-09-22 23:14:15
- Modify Date: 2024-01-03 17:39:29
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Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma[1].
| Name | cinalukast |
|---|---|
| Synonyms |
Cinalukast
4-[3-[(E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl]anilino]-2,2-diethyl-4-oxobutanoic acid |
| Description | Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6.4 nM (LTD4)[1] |
| In Vitro | Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50 value of 6.4 nM[1]. Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKB value of 9.3[1]. |
| In Vivo | Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively[1]. Animal Model: Guinea pigs[1] Dosage: 10 mg/kg Administration: Oral gavage; 10 mg/kg once Result: Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs. |
| Density | 1.258g/cm3 |
|---|---|
| Molecular Formula | C23H28N2O3S |
| Molecular Weight | 412.54500 |
| Exact Mass | 412.18200 |
| PSA | 107.53000 |
| LogP | 5.87360 |
| Index of Refraction | 1.655 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |