499-04-7

499-04-7 structure

Name: Arecaidine
Chemical Name: 1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid
CAS Number: 499-04-7
Molecular Formula: C₇H₁₁NO₂
Molecular Weight: 141.168
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-12-22 11:14:14
Modify Date: 2024-01-02 10:58:44
Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

Name	1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid
Synonyms	1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid 1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid Arecaidine 1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-

Description	Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22. [2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,501,1984

HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%