Arecaidine

Modify Date: 2025-08-25 21:58:03

Arecaidine structure	Common Name	Arecaidine
	CAS Number	499-04-7	Molecular Weight	141.168
	Density	1.2±0.1 g/cm3	Boiling Point	266.7±35.0 °C at 760 mmHg
	Molecular Formula	C₇H₁₁NO₂	Melting Point	232ºC (dec.)
	MSDS	N/A	Flash Point	115.1±25.9 °C

Use of Arecaidine

Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

Name	1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid
Synonym	More Synonyms

Description	Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22. [2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

Description

Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

References

[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.

[2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

Density	1.2±0.1 g/cm3
Boiling Point	266.7±35.0 °C at 760 mmHg
Melting Point	232ºC (dec.)
Molecular Formula	C₇H₁₁NO₂
Molecular Weight	141.168
Flash Point	115.1±25.9 °C
Exact Mass	141.078979
PSA	40.54000
LogP	0.77
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.524

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT2070800

CHEMICAL NAME :: Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-

CAS REGISTRY NUMBER :: 499-04-7

BEILSTEIN REFERENCE NO. :: 0112366

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H11-N-O2

MOLECULAR WEIGHT :: 141.19

WISWESSER LINE NOTATION :: T6N CUTJ A1 CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 mg/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,501,1984

HS Code	2933399090

Precursor 10
CAS#:300-08-3 Arecoline hydro... CAS#:562-54-9 Potassium Methy... CAS#:50-00-0 Formaldehyde CAS#:63-75-2 Arecoline
CAS#:37673-66-8 ethyl 4-hydroxy... CAS#:535-83-1 Trigonelline CAS#:25012-72-0 Ethyl 1-methyl-... CAS#:6315-60-2 N,N-DI-(BETA-CA...
CAS#:5657-66-9 3-cyano-1-methy... CAS#:13221-89-1 Methyl 1-methyl...
DownStream 7
CAS#:74-89-5 methylamine CAS#:26070-52-0 N,N-diethyl-1-m... CAS#:28125-84-0 ETHYL 1-METHYL-... CAS#:35516-99-5 prop-2-ynyl 1-m...
CAS#:5497-44-9 1,2,5,6-Tetrahy... CAS#:5497-45-0 butyl 1-methyl-... CAS#:63-75-2 Arecoline

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid

1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Arecaidine

1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid

3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-

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Arecaidine

Use of Arecaidine

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Arecaidine Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.