Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: Propanedinitrile,2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-
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10537-47-0

10537-47-0 structure

Name: Malonoben
Chemical Name: malonoben
CAS Number: 10537-47-0
Molecular Formula: C₁₈H₂₂N₂O
Molecular Weight: 282.380
Catalog: Biochemical Amino acids and their derivatives Tyrosine derivatives
Create Date: 2018-08-05 11:09:24
Modify Date: 2026-07-03 08:38:57
Tyrphostin A9(AG 17), a tyrosine kinase inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. IC50 value: Target: Multi tyrosine kinaseTyrphostin A9 inhibited TNF-induced tyrosine phosphorylation of pyk2 without blocking the cells' bactericidal activity. Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor (IC50 = 500 nM). Recent findings suggest that signaling via PDGF receptor tyrosine kinases is not necessary for the shift of the smooth muscle cells from a contractile to a synthetic phenotype. On the other hand these enzymes apparently carry out important functions in the control of intracellular membrane traffic and cell division.

Name	malonoben
Synonyms	[[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]METHYLENE]-PROPANEDINITRILE 2-(3,5-di-tert-butyl-4-hydroxybenzylidene)malononitrile 3,5-di-tert-butyl-4-hydroxybenzylidene-malononitril MALONOBEN TYRPHOSTIN A9 //BP Tyrphostin 9, PDGFR tyrosine kinase inhibitor Malonoben Tyrphostin 9 p5126 TYRPHOSTIN RG Tyrphostin 9/AG9 GCP 5126 Tyrphostin A9 (AG 17) Caswell No. 291AA Malonobene MFCD00209853 (3,5-Di-tert-butyl-4-hydroxybenzylidene)malononitrile 2-((3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)methylene)propanedinitrile Tyrphostin9 Tyrphostin 9(AG-17) s-15126 ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)CINNAMONITRILE ent27910 TYRPHOSTIN A9OLECBOXYLATE tyrphostin A9 2-(3,5-di-tert-butyl-4-hydroxybenzylidene)Malononitrile 2-[(3,5-DITERT-BUTYL-4-HYDROXYPHENYL)METHYLIDENE]PROPANEDINITRILE TYRPHOSTIN 9;NSC 242557; RG-50872;AG 17; P AG 17 - - Calbiochem 3,5-DI-T-BUTYL-4-HYDROXY-BENZYLIDENEMALONONITRILE TYRPHOSTIN AG 17 Propanedinitrile, 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene] Tyrphostin AG17 RECHEM AL BX 0198 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile TYRPHOSTIN 9 AG 17 TYRPHOSTIN 9;MALONOBEN;TYRPHOSTIN AG-17;SF 6847;P 5126;RG-50872;NSC Tyrphostin 9 ，S2895 CHEMBRDG-BB 3,5-DI-TERT-BUTYL-4-HYDROXYBENZYLIDENEMALONONITRILE 3,5-di-tert-butyl-4-hydroxybenzylidene-malononitrile (3,5-Di-tert-butyl-4-hydroxybenzyliden)malononitril gulfs-15126 2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile Tyrphostin 9 Tyrphostin A9, 10 mM in DMSO MALONABEN [4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]malononitrile C17896100 Tyrphostin A9 2,6-Di-tert-butyl-4-(2,2-dicyanovinyl)phenol 3,5-di-tert-Butyl-4-hydroxybenzylidenemalonitrile (3,5-di-tert-butyl-4-hydroxybenzylidene)propanedinitrile [(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile TYRPHOSTIN A9 \ SELECTIVE PDGF TYROSINE ((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-propanedinitril TYRPHOSTIN A9

Description	Tyrphostin A9(AG 17), a tyrosine kinase inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. IC50 value: Target: Multi tyrosine kinaseTyrphostin A9 inhibited TNF-induced tyrosine phosphorylation of pyk2 without blocking the cells' bactericidal activity. Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor (IC50 = 500 nM). Recent findings suggest that signaling via PDGF receptor tyrosine kinases is not necessary for the shift of the smooth muscle cells from a contractile to a synthetic phenotype. On the other hand these enzymes apparently carry out important functions in the control of intracellular membrane traffic and cell division.
Related Catalog	Research Areas >> Cancer
References	[1]. Park SJ, Park YJ, Shin JH, et al. A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Biochem Biophys Res Commun. 2011 May 13;408(3):465-70. [2]. Richard F. Loeser, Christopher B. Forsyth, Allen M. Samarel et al. Fibronectin Fragment Activation of Proline-rich Tyrosine Kinase PYK2 Mediates Integrin Signals Regulating Collagenase-3 Expression by Human Chondrocytes through a Protein Kinase C-dependent Pathway. The Journal of Biological Chemistry, 2003, 278, 24577-24585. [3]. Michele Fuortes, Maxine Melchior, Hyunsil Han, et al. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J Clin Invest. 1999;104(3):327-335. [4]. Johan Thyberg . Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. European Journal of Cell Biology.1998,76(1): 33-42 [5]. R Marhaba, F Mary, C Pelassy, et al. Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. The Journal of Immunology. 1996,157 (4): 1468-1473

Density	1.1±0.1 g/cm3
Boiling Point	386.8±37.0 °C at 760 mmHg
Melting Point	141-143℃ (ethanol )
Molecular Formula	C₁₈H₂₂N₂O
Molecular Weight	282.380
Flash Point	187.7±26.5 °C
Exact Mass	282.173218
PSA	67.81000
LogP	4.81
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.555
Storage condition	Store at RT
Water Solubility	ethanol: 20 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO3737000

CHEMICAL NAME :: Malononitrile, 3,5-di-tert-butyl-4-hydroxybenzylidene-

CAS REGISTRY NUMBER :: 10537-47-0

BEILSTEIN REFERENCE NO. :: 2700764

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H22-N2-O

MOLECULAR WEIGHT :: 282.42

WISWESSER LINE NOTATION :: NCYCN&U1R DQ CX1&1&1 EX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 87 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,21,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 226 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 74-1,-,1974

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H311-H331
Precautionary Statements	P261-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R23/24/25
Safety Phrases	S36/37/39-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	OO3737000
Hazard Class	6.1
HS Code	2926909090

109-77-3

1620-98-0

~84%

10537-47-0

Literature: Hori, Hitoshi; Nagasawa, Hideko; Ishibashi, Masaki; Uto, Yoshihiro; Hirata, Akihiko; Saijo, Kouichi; Ohkura, Kazuto; Kirk, Kenneth L; Uehara, Yoshimasa Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 10 p. 3257 - 3265

Precursor 2
109-77-3 1620-98-0
DownStream 0

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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