120667-15-4

120667-15-4 structure

Name: (RS)-PPG
Chemical Name: 2-(4-phosphonoanilino)acetic acid
CAS Number: 120667-15-4
Molecular Formula: C₈H₁₀NO₅P
Molecular Weight: 231.14200
Catalog: Biochemical Amino acids and their derivatives Glycine derivatives
Create Date: 2018-09-16 14:52:29
Modify Date: 2024-01-10 15:56:20
(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].

Name	2-(4-phosphonoanilino)acetic acid
Synonyms	4-phosphonophenylglycine

Description	(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	hmGluR4a:5.2 μM (EC50) hmGluR6:4.7 μM (EC50) hmGluR7b:185 μM (EC50) hmGluR8a:0.2 μM (EC50)
In Vitro	Activation of group III mGluRs by treatment of neurons with (R,S)-PPG (100 μM) can significantly suppress the elevation of intracellular calcium and protect neurons from apoptosis induced by Aβ[31-35] (25 μM)[2].
References	[1]. Gasparini F, et al. (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J Pharmacol Exp Ther. 1999 Jun;289(3):1678-87. [2]. Zhao L, et al. Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons. Neurotox Res. 2009 Aug;16(2):174-83.