(RS)-PPG

Modify Date: 2024-01-10 15:56:20

(RS)-PPG structure	Common Name	(RS)-PPG
	CAS Number	120667-15-4	Molecular Weight	231.14200
	Density	1.58 g/cm3	Boiling Point	583.5ºC at 760 mmHg
	Molecular Formula	C₈H₁₀NO₅P	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of (RS)-PPG

(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].

Name	2-(4-phosphonoanilino)acetic acid
Synonym	More Synonyms

Description	(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	hmGluR4a:5.2 μM (EC50) hmGluR6:4.7 μM (EC50) hmGluR7b:185 μM (EC50) hmGluR8a:0.2 μM (EC50)
In Vitro	Activation of group III mGluRs by treatment of neurons with (R,S)-PPG (100 μM) can significantly suppress the elevation of intracellular calcium and protect neurons from apoptosis induced by Aβ[31-35] (25 μM)[2].
References	[1]. Gasparini F, et al. (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J Pharmacol Exp Ther. 1999 Jun;289(3):1678-87. [2]. Zhao L, et al. Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons. Neurotox Res. 2009 Aug;16(2):174-83.

Density	1.58 g/cm3
Boiling Point	583.5ºC at 760 mmHg
Molecular Formula	C₈H₁₀NO₅P
Molecular Weight	231.14200
Exact Mass	231.03000
PSA	130.66000
LogP	0.27430
Vapour Pressure	1.85E-14mmHg at 25°C
Index of Refraction	1.617
Storage condition	Store at RT
Water Solubility	DMSO: soluble2mg/mL

4-phosphonophenylglycine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (RS)-3-HYDROXYPHENYLGLYCINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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