133550-37-5

133550-37-5 structure
133550-37-5 structure
  • Name: Tyrphostin AG 835
  • Chemical Name: Tyrphostin B44, (+) enantiomer,(S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
  • CAS Number: 133550-37-5
  • Molecular Formula: C18H16N2O3
  • Molecular Weight: 308.33100
  • Catalog: Signaling Pathways JAK/STAT Signaling EGFR
  • Create Date: 2017-05-19 18:22:25
  • Modify Date: 2024-01-09 18:29:20
  • (+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) is an EGRF inhibitor with antitumor activities[1].

Name Tyrphostin B44, (+) enantiomer,(S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
Synonyms AG 835
TYRPHOSTIN AG 835
Tyrphostin AG 835
TYRPHOSTIN B50
Description (+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) is an EGRF inhibitor with antitumor activities[1].
Related Catalog
In Vitro (+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) (0-100 µM) inhibits cell survival with EC50 values of 3.12, 12.5 and 12.5 µM against CALO, INBL and HeLa cells, respectively[1].
References

[1]. Soto-Cruz I, et al. The tyrphostin B42 inhibits cell proliferation and HER-2 autophosphorylation in cervical carcinoma cell lines. Cancer Invest. 2008 Mar;26(2):136-44.

Density 1.299g/cm3
Boiling Point 603ºC at 760mmHg
Melting Point 146 °C
Molecular Formula C18H16N2O3
Molecular Weight 308.33100
Flash Point 318.5ºC
Exact Mass 308.11600
PSA 93.35000
LogP 3.27308
Vapour Pressure 3.9E-15mmHg at 25°C
Index of Refraction 1.66
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22
RIDADR NONH for all modes of transport