38103-61-6
38103-61-6 structure
- Name: tolamolol
- Chemical Name: 4-[2-[[2-hydroxy-3-(2-methylphenoxy)propyl]amino]ethoxy]benzamide
- CAS Number: 38103-61-6
- Molecular Formula: C19H24N2O4
- Molecular Weight: 344.40500
- Create Date: 2018-04-01 08:00:00
- Modify Date: 2024-02-02 01:28:31
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Tolamolol is a selective β-adrenergic blocker that significantly reduces the degree of exercise-induced inhibition of the S-T segment and can be used in the treatment of cardiac arrhythmias.
| Name | 4-[2-[[2-hydroxy-3-(2-methylphenoxy)propyl]amino]ethoxy]benzamide |
|---|---|
| Synonyms |
4-(2-{[2-hydroxy-3-(2-methylphenoxy)propyl]amino}ethoxy)benzamide
Tolamolol (USAN/INN) tolamolol,(+-)-isomer TOLAMOLOL UK-6558-01 [14C]-Tolamolol Tolamololum [INN-Latin] Tolamololum |
| Description | Tolamolol is a selective β-adrenergic blocker that significantly reduces the degree of exercise-induced inhibition of the S-T segment and can be used in the treatment of cardiac arrhythmias. |
|---|---|
| In Vivo | Forty-two patients with angina pectoris have completed a randomized, double-blind trial comparing Tolamolol 100 mg and 200 mg with propranolol 80 mg, practolol 100 mg, and placebo, all given three times a day. Tolamolol 200 mg thrice daily was found to be equivalent to propranolol 80 mg thrice daily in anti-anginal efficacy. Anginal attack rates and trinitrin consumption were significantly reduced by all active treatments as compared with the placebo but Tolamolol and propranolol were the most effective. Tolamolol 200 mg thrice daily was most effective in reducing blood pressure, while propranolol was most effective in reducing the resting heart rate. All treatments except the placebo significantly increased the amount of exercise that could be performed before angina appeared (exercise work), while the Tolamolol 200 mg thrice daily significantly reduced Robinson's index when compared with all other active agents.[1] |
| References | 1. Jackson G, et al. Double-blind comparison of tolamolol, propranolol, practolol, and placebo in the treatment of angina pectoris. Br Med J. 1975 Mar 29;1(5960):708-12. |
| Density | 1.189g/cm3 |
|---|---|
| Boiling Point | 595.2ºC at 760mmHg |
| Molecular Formula | C19H24N2O4 |
| Molecular Weight | 344.40500 |
| Flash Point | 313.8ºC |
| Exact Mass | 344.17400 |
| PSA | 93.81000 |
| LogP | 2.59340 |
| Index of Refraction | 1.581 |
| HS Code | 2924299090 |
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38103-61-6 |
| Literature: Augstein; Cox; Ham; Leeming; Snarey Journal of Medicinal Chemistry, 1973 , vol. 16, # 11 p. 1245 - 1251 |
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |