Name | 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid,3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol |
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Synonyms |
Telopar (TN)
EINECS 272-332-6 UNII-UPY1D732T0 Telopar HMS2093L04 Oxantel embonate Oxantel pamoate (USAN) OXANTEL PAMOATE Oxantel (pamoate) |
Description | Oxantel pamoate is a widely available dewormer, potently against Trichuris muris and Hookworms. |
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Related Catalog | |
Target |
Antiparasitic[1] |
In Vivo | The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus[1]. |
References |
Density | 1.09 g/cm3 |
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Boiling Point | 383.1ºC at 760 mmHg |
Molecular Formula | C36H32N2O7 |
Molecular Weight | 604.65 |
Flash Point | 185.5ºC |
PSA | 186.72000 |
LogP | 7.41720 |
Storage condition | -20℃ |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
WGK Germany | 3 |