153212-75-0
153212-75-0 structure
- Name: 6α-Hydroxy paclitaxel
- Chemical Name: 6-hydroxypaclitaxel
- CAS Number: 153212-75-0
- Molecular Formula: C47H51NO15
- Molecular Weight: 869.906
- Catalog: Research Areas Cancer
- Create Date: 2018-07-21 14:30:12
- Modify Date: 2025-08-26 18:38:41
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6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer[1].
| Name | 6-hydroxypaclitaxel |
|---|---|
| Synonyms |
(2α,3ξ,5β,6α,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,6,7-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
6α-Hydroxy Paclitaxel Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,3S,4R,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4 a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,3S,4R,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4a,8,1 3,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 6-Hydroxytaxol 6-hydroxypaclitaxel |
| Description | 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer[1]. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 979.8±65.0 °C at 760 mmHg |
| Melting Point | 177-180ºC |
| Molecular Formula | C47H51NO15 |
| Molecular Weight | 869.906 |
| Flash Point | 546.4±34.3 °C |
| Exact Mass | 869.325867 |
| PSA | 241.52000 |
| LogP | 7.32 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.646 |
| Storage condition | 2-8°C |
| Hazard Codes | Xn |
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