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29984-33-6

29984-33-6 structure
29984-33-6 structure
  • Name: Vidarabine phosphate
  • Chemical Name: 9H-Purin-6-amine,9-(5-O-phosphono-b-D-arabinofuranosyl)
  • CAS Number: 29984-33-6
  • Molecular Formula: C10H14N5O7P
  • Molecular Weight: 347.221
  • Catalog: Biochemical Carbohydrate Monosaccharide
  • Create Date: 2018-10-01 08:17:18
  • Modify Date: 2024-01-08 15:39:40
  • Vidarabine phosphate (Ara-AMP), an antiviral agent, inhibits chronic HBV infection[1][2]. Vidarabine phosphate also against herpes simplex and varicella zoster viruses[3].

Name 9H-Purin-6-amine,9-(5-O-phosphono-b-D-arabinofuranosyl)
Synonyms 9-(5-O-Phosphono-b-D-arabinofuranosyl)-9H-purin-6-amine
9H-Purin-6-amine, 9-(5-O-phosphono-β-D-arabinofuranosyl)-
Adenosin-5'-phosphat
9-(5-O-Phosphono-b-D-arabinofuranosyl)adenine
9-β-D-Arabinofuranosyladenine 5'-monophosphate
adeninearabinosidemonophosphate
arabinosyladeninemonophosphate
cl-808
vidarabinemonophosphate
ARA-AMP
Ara-A
EINECS 249-990-8
Vidarabine phosphate
Vidarabine Monophasphate
9H-Purin-6-amine, 9- (5-O-phosphono-β-D-arabinofuranosyl)-
9-(5-O-Phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine
adenosine-5-monophosphate
9-b-D-Arabinofuranosyladenine 5'-Monophosphate
Density 2.3±0.1 g/cm3
Boiling Point 798.5±70.0 °C at 760 mmHg
Melting Point 213ºC
Molecular Formula C10H14N5O7P
Molecular Weight 347.221
Flash Point 436.7±35.7 °C
Exact Mass 347.063080
PSA 195.88000
LogP -0.22
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.905
Water Solubility Soluble in water at 4mg/ml
Name: Adenine-9-Beta-D-Arabinofuranoside- 5 -Monophosphate 98% Material Safety Data Sheet
Synonym: 9-(5-O-Phosphono-3-D-Arabinofuranosyl)-9H-Purin-6-Amine; Arabinosyladenine Monophosphate
CAS: 29984-33-6
Section 1 - Chemical Product MSDS Name:Adenine-9-Beta-D-Arabinofuranoside- 5 -Monophosphate 98% Material Safety Data Sheet
Synonym:9-(5-O-Phosphono-3-D-Arabinofuranosyl)-9H-Purin-6-Amine; Arabinosyladenine Monophosphate

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
29984-33-6 Adenine-9--D-Arabinofuranoside-5'-Mon 98 249-990-8
Hazard Symbols: XN
Risk Phrases: 20/22

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation and if swallowed.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May cause central nervous system effects.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 29984-33-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 213 deg C
Autoignition Temperature: Not applicable.
Flash Point: 205 deg C ( 401.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 205 deg C
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H14N5O7P
Molecular Weight: 347.22

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, oxides of phosphorus, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 29984-33-6: AU6204000 LD50/LC50:
Not available.
Carcinogenicity:
Adenine-9--D-Arabinofuranoside-5'-Monophosphate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/22 Harmful by inhalation and if swallowed.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 37/39 Wear suitable gloves and eye/face
protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 29984-33-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 29984-33-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 29984-33-6 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU6204000
CHEMICAL NAME :
Adenine, 9-beta-D-arabinofuranosyl-, 5'-(dihydrogen phosphate)
CAS REGISTRY NUMBER :
29984-33-6
LAST UPDATED :
199509
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H14-N5-O7-P
MOLECULAR WEIGHT :
347.26
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ E1OPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 284,6,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 284,6,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2800 mg/kg/28D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,1,1983
Hazard Codes Xn:Harmful;
Risk Phrases R20/22
Safety Phrases S24/25-S37/39
RIDADR UN 2811
RTECS AU6204000
Packaging Group II
Hazard Class 6.1(a)
HS Code 29400090

~76%

29984-33-6 structure

29984-33-6

Literature: Journal of Pharmaceutical Sciences, , vol. 73, # 2 p. 278 - 280

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29984-33-6 structure

29984-33-6

Literature: US4123609 A1, ;
Precursor  2

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