Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Coronaridine
Price: ￥3438.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Coronaridine
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ibogamine-18-carboxylic acid, methyl ester, hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

467-77-6

467-77-6 structure

467-77-6 structure

Name: Coronaridine
Chemical Name: Coronaridine
CAS Number: 467-77-6
Molecular Formula: C₂₁H₂₆N₂O₂
Molecular Weight: 338.44300
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2017-05-26 12:49:05
Modify Date: 2024-01-04 17:50:56
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression[1].

Name	Coronaridine
Synonyms	cornigerine 1,2-(methylenedioxy)-1,2-dimethylcolchicine Dihydrocatharanthin (+-)-Coronaridin (-)-1,2-(Methylenedioxy)-1,2-didemethoxycolchicine ibogamine-18-carboxylic acid methyl ester Acetamide,N-(6,7,8,10-tetrahydro-4,11-dimethoxy-10-oxoheptaleno(1,2-e)-1,3-benzodioxol-8-yl)-,(S) n-(4,11-dimethoxy-10-oxo-6,7,8,10-tetrahydroheptaleno[1',2':3,4]benzo[1,2-d][1,3]dioxol-8-yl)acetamide Catharanthin EINECS 207-398-7

Description	Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Neurological Disease
In Vitro	Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC50 values >40 μM. It agaisnt wnt-dependent cells with IC50 values of 10.4, 11.6 and 24.4 μM for SW480, HCT116 and DLD1cells, respectively[1]. Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β--catenin at Ser33, Ser37, and Thr41 and p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged[1]. In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC30 value for each receptor subtype. Both congeners potentiated different GABAARs in a concentration-dependent manner[2]. At higher concentrations, however, Catharanthine starts to inhibit GABA-activated currents due to the reduced amplitude and rebound current, where the threshold concentration depended on the receptor subtype (e.g., > 30 μM for hα1β2; > 100 μM for hα1β2γ2 and hα2β2γ2). The PAM activity of Catharanthine's are depended on the receptor subtype: hα1β2 (4.6±0.8 μM), >hα2β2γ2 (12.6±3.8 μM), hα1β2γ2 (14.4 ± 4.6 μM)[2].
References	[1]. Kensuke Ohishi, et al. Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits the Wnt signaling pathway by decreasing β-catenin mRNA expression. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3937-40. [2]. Hugo R Arias, et al. Coronaridine congeners potentiate GABA A receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jul 13;101:109930

Density	1.24g/cm3
Boiling Point	488.1ºC at 760 mmHg
Melting Point	92-93 ºC
Molecular Formula	C₂₁H₂₆N₂O₂
Molecular Weight	338.44300
Flash Point	249ºC
Exact Mass	338.19900
PSA	45.33000
LogP	3.19310
Vapour Pressure	1.12E-09mmHg at 25°C
Index of Refraction	1.642
Water Solubility	Practically insoluble (0.024 g/L) (25 ºC)