57343-54-1

57343-54-1 structure

Name: DQn-1
Chemical Name: 4-[(2,4-diamino-5-chloroquinazolin-6-yl)methylamino]benzoic acid
CAS Number: 57343-54-1
Molecular Formula: C₁₆H₁₄ClN₅O₂
Molecular Weight: 343.77
Create Date: 2016-11-27 11:02:40
Modify Date: 2024-01-02 20:55:11
DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1].

Name	4-[(2,4-diamino-5-chloroquinazolin-6-yl)methylamino]benzoic acid

Description	DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC90=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC50s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	DQn-1 抑制 Mycobacterium tuberculosis，MIC90 值分别为 0.03 µM 和 1 µM[1]。
In Vivo	DQn-1 (5-10 mg/kg; p.o. for 8 days) 未能检测到小鼠 Mtb 负荷有任何显着降低[1]。
References	[1]. Kumar A, et, al. A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis. ACS Infect Dis. 2015 Dec 11;1(12):604-14.

108947-99-5

~90%

57343-54-1

Literature: Hynes; Kumar; Tomazic; Washtien Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1515 - 1519

18144-47-3

57343-54-1

Literature: Hynes; Kumar; Tomazic; Washtien Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1515 - 1519

18917-75-4

57343-54-1

Literature: Hynes; Kumar; Tomazic; Washtien Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1515 - 1519

Precursor 3
108947-99-5 18144-47-3 18917-75-4
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