21273-38-1

21273-38-1 structure
21273-38-1 structure
  • Name: Phenoxyethanol-d2
  • Chemical Name: 1,1-dideuterio-2-phenoxyethanol
  • CAS Number: 21273-38-1
  • Molecular Formula: C8H8D2O2
  • Molecular Weight: 140.17600
  • Catalog: Research Areas Infection
  • Create Date: 2018-03-13 08:00:00
  • Modify Date: 2024-01-10 10:43:56
  • Phenoxyethanol-d2 is the deuterium labeled Phenoxyethanol[1]. Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al[2].

Name 1,1-dideuterio-2-phenoxyethanol
Synonyms 2-Phenoxyethanol-1,1-d2
1,2-D2-phenoxyethanol
Description Phenoxyethanol-d2 is the deuterium labeled Phenoxyethanol[1]. Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. B Dréno, et al. Safety Review of Phenoxyethanol When Used as a Preservative in Cosmetics. J Eur Acad Dermatol Venereol. 2019 Nov;33 Suppl 7:15-24.  

Molecular Formula C8H8D2O2
Molecular Weight 140.17600
Exact Mass 140.08100
PSA 29.46000
LogP 1.05770
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
RIDADR NONH for all modes of transport
Precursor  3

DownStream  0