DC Chemicals Limited
China
Product Name: Bay K-8644
Price: $600.0/100mg $1000.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

71145-03-4

71145-03-4 structure

Name: Bay K-8644
Chemical Name: 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylic acid methyl ester
CAS Number: 71145-03-4
Molecular Formula: C₁₆H₁₅F₃N₂O₄
Molecular Weight: 356.29700
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2018-12-31 14:46:08
Modify Date: 2024-01-12 09:34:31
Bay K 8644, a dihydropyridine compound, is a specific L-type Ca2+ channel agonist. Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel[1].

Name	1,4-Dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylic acid methyl ester
Synonyms	(1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-pyridine carboxylic acid methyl ester rac-Aziridin-2-carbonitril methyl-1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)-pyridine-3-carboxylate (+/-)-Aziridin-2-carbonitril cyano-2 aziridine (-)-2,6-dimethyl-3-carbomethoxy-5-nitro-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine 2-aziridinecarbonitrile MFCD00036697 2-cyano-2-aziridine (.+/-.)-Bay K 8644 nitrile of aziridine-2-carboxylic acid Bay K-8644

Description	Bay K 8644, a dihydropyridine compound, is a specific L-type Ca2+ channel agonist. Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
In Vitro	In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development[2].
In Vivo	A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats[1].
References	[1]. H Satoh, et al. Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects. Circ Res. 1998 Dec 14-28;83(12):1192-204. [2]. J P Gomez, et al. Effects of Bay K 8644 on L-type calcium current from newborn rat cardiomyocytes in primary culture. J Mol Cell Cardiol. 1996 Oct;28(10):2217-29. [3]. N Ives,et al. BAY k 8644, a calcium channel agonist, reverses hypotension in endotoxin-shocked rats. Eur J Pharmacol. 1986 Nov 4;130(3):169-75.

Density	1.37g/cm3
Boiling Point	404.3ºC at 760 mmHg
Molecular Formula	C₁₆H₁₅F₃N₂O₄
Molecular Weight	356.29700
Flash Point	198.3ºC
Exact Mass	356.09800
PSA	84.15000
LogP	4.19940
Index of Refraction	1.545
Storage condition	-20℃

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport