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Product Name: Etidocaine Hydrochloride
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36637-19-1

36637-19-1 structure

36637-19-1 structure

Name: Etidocaine Hydrochloride
Chemical Name: N-(2,6-dimethylphenyl)-2-[ethyl(propyl)amino]butanamide,hydrochloride
CAS Number: 36637-19-1
Molecular Formula: C₁₇H₂₉ClN₂O
Molecular Weight: 312.87800
Catalog: Research Areas Others
Create Date: 2016-01-07 00:46:56
Modify Date: 2024-01-03 09:56:56
Etidocaine (hydrochloride) is a long aminoamide local anesthetic[1].

Name	N-(2,6-dimethylphenyl)-2-[ethyl(propyl)amino]butanamide,hydrochloride
Synonyms	Duranest Hydrochloride Etidocaine HCl Etidocaine hydrochloride

Description	Etidocaine (hydrochloride) is a long aminoamide local anesthetic[1].
Related Catalog	Research Areas >> Infection Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	IGL-EDC formulations can induce a significant increase in human fibroblasts survival[1]. Cell Viability Assay Cell Line: Human fibroblasts cells Concentration: 0, 4, 8, 16, 24 mM Incubation Time: 4, 6 and 24 h Result: Showed that cell survival decreased in a (EDC) concentration with time-dependent manner.
In Vivo	Etidocaine (spinal injection, 0.0075%, once) does not show postinjection neurologic deficit[2]. Animal Model: Adult Swiss Webster male mice[2] Dosage: 0.0075% Administration: Etidocaine (spinal injection, 0.0075%, once) Result: Did not show postinjection neurologic deficit.
References	[1]. Oliveira, et al. Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity. Pharmaceutical research vol. 35, 12 229. 10 Oct. 2018. [2]. Langerman, L, et al. The partition coefficient as a predictor of local anesthetic potency for spinal anesthesia: evaluation of five local anesthetics in a mouse model. Anesthesia and analgesia vol. 79,3 (1994): 490-4.

Boiling Point	389.7ºC at 760 mmHg
Molecular Formula	C₁₇H₂₉ClN₂O
Molecular Weight	312.87800
Flash Point	189.5ºC
Exact Mass	312.19700
PSA	35.83000
LogP	5.20390

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EU5435000

CHEMICAL NAME :: 2',6'-Butyroxylidide, 2-(N-ethylpropylamino)-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 36637-19-1

LAST UPDATED :: 199109

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C17-H28-N2-O.Cl-H

MOLECULAR WEIGHT :: 312.93

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64400 ug/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant Behavioral - somnolence (general depressed activity)

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 60,385,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 99 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 61,1829,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 61,1829,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58178 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 21,277,1990

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 37,13,1976