36637-19-1

• 常用中文名：依替卡因-d9盐酸盐
• 常用英文名：Etidocaine Hydrochloride
• CAS号：36637-19-1
• 分子式：C₁₇H₂₉ClN₂O
• 分子量：312.87800
• 相关类别： 研究领域 其他
• 发布时间：2016-01-07 00:46:56
• 更新时间：2024-01-03 09:56:56
• 阿替卡因(盐酸)是一种长氨基酰胺局部麻醉剂[1]。

名称

• 中文名: 依替卡因-d9盐酸盐
• 英文名: N-(2,6-dimethylphenyl)-2-[ethyl(propyl)amino]butanamide,hydrochloride
• 英文别名: Duranest Hydrochloride; Etidocaine HCl; Etidocaine hydrochloride

物化性质

• 沸点: 389.7ºC at 760 mmHg
• 分子式: C₁₇H₂₉ClN₂O
• 分子量: 312.87800
• 闪点: 189.5ºC
• 精确质量: 312.19700
• PSA: 35.83000
• LogP: 5.20390

生物活性

• 描述: 阿替卡因(盐酸)是一种长氨基酰胺局部麻醉剂[1]。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: IGL-EDC制剂可诱导人成纤维细胞存活率显著增加[1]。细胞存活率测定细胞系：人成纤维细胞浓度：0、4、8、16、24 mM孵育时间：4、6和24 h结果：细胞存活率在(EDC)浓度下以时间依赖性方式下降。
• 体内研究: 阿替卡因(脊髓注射,0.0075%,一次)未显示注射后神经功能缺损[2]。动物模型：成年Swiss Webster雄性小鼠[2]剂量：0.0075%给药：依替卡因(脊髓注射,0.007%,一次)结果：未显示注射后神经功能缺损。
• 参考文献:

  [1]. Oliveira, et al. Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity. Pharmaceutical research vol. 35, 12 229. 10 Oct. 2018.

  [2]. Langerman, L, et al. The partition coefficient as a predictor of local anesthetic potency for spinal anesthesia: evaluation of five local anesthetics in a mouse model. Anesthesia and analgesia vol. 79,3 (1994): 490-4.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EU5435000 CHEMICAL NAME : 2',6'-Butyroxylidide, 2-(N-ethylpropylamino)-, hydrochloride, (+-)- CAS REGISTRY NUMBER : 36637-19-1 LAST UPDATED : 199109 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C17-H28-N2-O.Cl-H MOLECULAR WEIGHT : 312.93 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 64400 ug/kg TOXIC EFFECTS : Behavioral - anticonvulsant Behavioral - somnolence (general depressed activity) REFERENCE : AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 60,385,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 99 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 61,1829,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6700 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 61,1829,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 58178 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 21,277,1990 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 37,13,1976