Name | 4-N-(1-benzylindazol-5-yl)-6-N,6-N-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine |
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Synonyms |
Lopac-G-0668
N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido[3,4-d]pyrimidine-4,6-diamine GW2974 |
Description | GW2974 is a potent dual inhibitor of EGFR and HER2 with IC50 value of 0.007 μM and 0.016 μM, respectively. GW2974 demonstrates in vitro inhibition of the EGFR and HER2 and inhibits the growth of tumor cell. GW2974 can be used for glioblastoma multiforme (GBM) disease research[1][2]. |
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Related Catalog | |
Target |
EGFRL858R/T790M:0.007 μM (IC50) HER2:0.016 μM (IC50) |
References |
Boiling Point | 645.6ºC at 760 mmHg |
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Molecular Formula | C23H21N7 |
Molecular Weight | 395.46 |
Flash Point | 344.3ºC |
Exact Mass | 395.18600 |
PSA | 71.76000 |
LogP | 4.30540 |
Vapour Pressure | 1.47E-16mmHg at 25°C |
Index of Refraction | 1.71 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |