127367-76-4
127367-76-4 structure
- Name: Frondoside A
- Chemical Name: Frondoside A hydrate
- CAS Number: 127367-76-4
- Molecular Formula: C60H95NaO29S
- Molecular Weight: 1335.43000
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-10-04 21:03:27
- Modify Date: 2024-01-09 18:59:32
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Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety[1][2].
| Name | Frondoside A hydrate |
|---|---|
| Synonyms | Frondoside A |
| Description | Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Caspase 3 Caspase-7 |
| In Vitro | Frondoside A (0-5 μM, 24 hours)causes concentration-dependent reduction in viability of lung and breast cancer cells through a caspase 3/7-dependent cell death pathway[2]. Cell Viability Assay[2] Cell Line: LNM35, A549, NCI-H460-Luc2, MDA-MB-435, MCF-7, and HepG2 cells. Concentration: 0-5 μM. Incubation Time: 24 hours. Result: Significantly and concentration-dependently inhibited cellular viability. Apoptosis Analysis[2] Cell Line: LNM35 cells. Concentration: 1-2.5 μM. Incubation Time: 24 hours. Result: Induced caspase-3/7 activity. |
| In Vivo | Frondoside A (0.01 and 1 mg/kg/ day i.p. for 25 days) significantly decreases the growth, the angiogenesis and lymph node metastasis of LNM35 tumor xenografts in mice, without obvious toxic side-effects[2]. Animal Model: LNM35 xenografts based on Six-week-old athymic NMRI female nude mice (nu/nu)[2]. Dosage: 0.01 and 1 mg/kg. Administration: IP. daily for 25 days. Result: Induced regression of established LNM35 xenografts. |
| References |
| Molecular Formula | C60H95NaO29S |
|---|---|
| Molecular Weight | 1335.43000 |
| Exact Mass | 1334.56000 |
| PSA | 431.24000 |