Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ro 41-0960
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Ro 41-0960
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: RO 41-0960 COMT IHIBITOR
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

125628-97-9

125628-97-9 structure

125628-97-9 structure

Name: Ro 41-0960
Chemical Name: (3,4-dihydroxy-5-nitrophenyl)-(2-fluorophenyl)methanone
CAS Number: 125628-97-9
Molecular Formula: C₁₃H₈FNO₅
Molecular Weight: 277.20500
Catalog: Signaling Pathways Metabolic Enzyme/Protease COMT
Create Date: 2017-02-03 18:02:54
Modify Date: 2024-01-02 23:14:40
Ro 41-0960 is a selective catechol-O-methyltransferase(COMT) inhibitor[1].

Name	(3,4-dihydroxy-5-nitrophenyl)-(2-fluorophenyl)methanone
Synonyms	OR 1139 3,4-dihydroxy-5-nitrophenyl 2-fluorophenyl ketone (3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone 2'-fluoro-3,4-dihydroxy-5-nitrobenzophenone 3,4-dihydroxy-5-nitro-2'-fluorobenzophenone Ro 41-0960 2'-Fluoro-3,4-dihydroxy-5-nitrobenzophenone Methanone,(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)

Description	Ro 41-0960 is a selective catechol-O-methyltransferase(COMT) inhibitor[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> COMT Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> COMT
References	[1]. Storch A, et al. Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons. Mol Pharmacol. 2000 Mar;57(3):589-94.

Density	1.536g/cm3
Boiling Point	489.9ºC at 760 mmHg
Molecular Formula	C₁₃H₈FNO₅
Molecular Weight	277.20500
Flash Point	250.1ºC
Exact Mass	277.03900
PSA	103.35000
LogP	2.89930
Vapour Pressure	3.2E-10mmHg at 25°C
Index of Refraction	1.656

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4952300

CHEMICAL NAME :: Methanone, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-

CAS REGISTRY NUMBER :: 125628-97-9

LAST UPDATED :: 199509

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H8-F-N-O5

MOLECULAR WEIGHT :: 277.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 312 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 72,952,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 69,64,1991

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	PC4952300