Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ro 41-0960
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Ro 41-0960
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: RO 41-0960 COMT IHIBITOR
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

125628-97-9

125628-97-9 structure

125628-97-9 structure

Name: Ro 41-0960
Chemical Name: (3,4-dihydroxy-5-nitrophenyl)-(2-fluorophenyl)methanone
CAS Number: 125628-97-9
Molecular Formula: C₁₃H₈FNO₅
Molecular Weight: 277.20500
Catalog: Signaling Pathways Metabolic Enzyme/Protease COMT
Create Date: 2017-02-03 18:02:54
Modify Date: 2025-09-03 05:25:43
Ro 41-0960 is a selective catechol-O-methyltransferase(COMT) inhibitor[1].

Name	(3,4-dihydroxy-5-nitrophenyl)-(2-fluorophenyl)methanone
Synonyms	OR 1139 3,4-dihydroxy-5-nitrophenyl 2-fluorophenyl ketone (3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone 2'-fluoro-3,4-dihydroxy-5-nitrobenzophenone 3,4-dihydroxy-5-nitro-2'-fluorobenzophenone Ro 41-0960 2'-Fluoro-3,4-dihydroxy-5-nitrobenzophenone Methanone,(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)

Description	Ro 41-0960 is a selective catechol-O-methyltransferase(COMT) inhibitor[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> COMT Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> COMT
References	[1]. Storch A, et al. Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons. Mol Pharmacol. 2000 Mar;57(3):589-94.

Density	1.536g/cm3
Boiling Point	489.9ºC at 760 mmHg
Molecular Formula	C₁₃H₈FNO₅
Molecular Weight	277.20500
Flash Point	250.1ºC
Exact Mass	277.03900
PSA	103.35000
LogP	2.89930
Vapour Pressure	3.2E-10mmHg at 25°C
Index of Refraction	1.656

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4952300

CHEMICAL NAME :: Methanone, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-

CAS REGISTRY NUMBER :: 125628-97-9

LAST UPDATED :: 199509

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H8-F-N-O5

MOLECULAR WEIGHT :: 277.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 312 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 72,952,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 69,64,1991

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	PC4952300

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.