254737-29-6
254737-29-6 structure
- Name: 2-MPPA
- Chemical Name: 2-(3-sulfanylpropyl)pentanedioic acid
- CAS Number: 254737-29-6
- Molecular Formula: C8H14O4S
- Molecular Weight: 206.25900
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Carboxypeptidase
- Create Date: 2016-02-11 00:42:40
- Modify Date: 2024-01-11 12:46:43
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2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM[1][2].
| Name | 2-(3-sulfanylpropyl)pentanedioic acid |
|---|---|
| Synonyms |
2-(3-mercaptopropyl)pentanedioic acid
2-MPPA Pentanedioic acid,2-(3-mercaptopropyl) |
| Description | 2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 90 nM (GCP II)[2] |
| In Vivo | 2-MPPA (10, 30 or 100 mg/kg) significantly attenuates Dizocilpine (HY-15084B) (0.1 mg/kg)-induced prepulse inhibition (PPI) deficits in mice, in a dose dependent manner. The efficacy of 2-MPPA on dizocilpine-induced PPI deficits is significantly antagonized by pretreatment with the selective group II metabotropic glutamate receptor (mGluR) antagonist LY341495 (HY-70059) (1.0 mg/kg)[1]. 2-MPPA (30 mg/kg) significantly prevents the deficit in SNCV induced by both 5 and 25 mg/kg taxol by 96.3 ± 4.4% and 98.3± 11.6% respectively[2]. 2-MPPA (10 mg/kg) inhibits tumor growth in the high expressor PSMA model CWR22RS by 70%[2]. |
| References |
| Molecular Formula | C8H14O4S |
|---|---|
| Molecular Weight | 206.25900 |
| Exact Mass | 206.06100 |
| PSA | 113.40000 |
| LogP | 1.26200 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |