1453-97-0

1453-97-0 structure

Name: 5-benzyloxygramine
Chemical Name: N,N-dimethyl-1-(5-phenylmethoxy-1H-indol-3-yl)methanamine
CAS Number: 1453-97-0
Molecular Formula: C₁₈H₂₀N₂O
Molecular Weight: 280.36400
Catalog: Research Areas Others
Create Date: 2018-03-11 08:00:00
Modify Date: 2025-08-25 10:31:32
5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1].

Name	N,N-dimethyl-1-(5-phenylmethoxy-1H-indol-3-yl)methanamine
Synonyms	5-benzyloxy-N,N-dimethylamino-3-methylindole EINECS 215-927-8 5-Benzyloxy-gramin 5-Benzyloxygramine MFCD00005631

Description	5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell[1].
References	[1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141.

50-00-0

1215-59-4

124-40-3

~94%

1453-97-0

Literature: Bandini, Marco; Eichholzer, Astrid Angewandte Chemie - International Edition, 2009 , vol. 48, # 50 p. 9533 - 9537

92438-11-4

1453-97-0

Literature: Journal of the American Chemical Society, , vol. 76, p. 5579,5584

6640-09-1

1453-97-0

Literature: Helvetica Chimica Acta, , vol. 38, p. 1452,1469

22424-59-5

1453-97-0

Literature: Helvetica Chimica Acta, , vol. 38, p. 1452,1469

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%