848193-68-0

848193-68-0 structure

Name: EX-527 (S-enantiomer)
Chemical Name: (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
CAS Number: 848193-68-0
Molecular Formula: C₁₃H₁₃ClN₂O
Molecular Weight: 248.708
Catalog: Research Areas Cancer
Create Date: 2019-01-01 07:04:09
Modify Date: 2024-01-13 07:35:41
Selisistat S-enantiomer (EX-527 S-enantiomer) is the S-enantiomer of Selisistat, with an IC50 of 123 nM for SIRT1. Selisistat S-enantiomer is much more potent than Selisistat R-enantiomer.

Name	(1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Synonyms	(S)-selisistat OCZ S1541_Selleck (1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide cc-651 1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1S)- EX527 EX-527 S-enantiomer EX-527 (S-enantiomer)

Description	Selisistat S-enantiomer (EX-527 S-enantiomer) is the S-enantiomer of Selisistat, with an IC50 of 123 nM for SIRT1. Selisistat S-enantiomer is much more potent than Selisistat R-enantiomer.
Related Catalog	Research Areas >> Cancer
Target	SIRT1:123 nM (IC50)
References	[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.