Top Suppliers:I want be here

131791-98-5

131791-98-5 structure
131791-98-5 structure
  • Name: Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
  • Chemical Name: Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(OSO3H)-Leu-D-Glu-OH
  • CAS Number: 131791-98-5
  • Molecular Formula: C64H86N10O25S
  • Molecular Weight: 1427.48000
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Thrombin
  • Create Date: 2017-09-05 23:18:23
  • Modify Date: 2024-07-21 18:27:42
  • Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM[1].

Name Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(OSO3H)-Leu-D-Glu-OH
Synonyms Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
Description Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM[1].
Related Catalog
References

[1]. Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27.  

[2]. Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34(3):1184-7.  

Molecular Formula C64H86N10O25S
Molecular Weight 1427.48000
Exact Mass 1426.55000
PSA 540.18000
LogP 2.81340